mucosal immune system

mucosal immune system

[myo̅o̅kō′səl]
the lymphoid tissues of the mucosal surfaces lining the GI, respiratory, and urogenital tracts.

mucosal immune system

Clusters of lymphoid cells beneath the mucosal endothelium of the gastrointestinal, respiratory, and genitourinary tracts that help protect the body from inhaled, consumed, or sexually transmitted infections. The system has two parts: organized and diffuse. The organized part (the mucosal-associated lymphoid tissue of the gastrointestinal and respiratory tracts) is composed of nodules containing lymphocytes and macrophages that are activated by ingested or inhaled microorganisms. The diffuse part is composed of loose clusters of macrophages and mature B and T lymphocytes found within the folds of the intestinal walls. The B cells secrete antibodies, primarily immunoglobulin A; the T cells directly lyse microorganisms.

The mucosal immune system is augmented by the presence of normal microflora; by peristalsis and cilia, which move mucus outward; and by various chemicals, such as gastric acid and pancreatic enzymes, which destroy pathogens. Normally all of these components must be functioning to prevent infection.

References in periodicals archive ?
Other articles discuss reproductive impacts of endocrine-disrupting chemicals on wildlife species and implications for conservation of endangered species; viable cell culture banking for biodiversity characterization and conservation; bio-banking genetic material for agricultural animal species; development and function of the mucosal immune system in the upper respiratory tract of neonatal calves; detection of emerging zoonotic pathogens: an integrated one health approach; a comprehensive review of animal models for fetal surgery; and catfish biology and farming.
Aging brings on changes in microbiota composition, mucosal immune system, and regeneration capacities in the gastrointestinal tract.
He has also pioneered the investigation of the mucosal immune system for the treatment of autoimmune and other diseases and the use of anti-CD3 to induce regulatory T cells for the treatment of these diseases.
The mucosal immune system : From dentistry to vaccine development Hiroshi KIYONO and Tatsuhiko AZEGAMI Communicated by Tatsuo SUDA, M.
The mucosal immune system consists of coordinated inductive and effector tissues (Fig.
We focus particularly on alcohol's effect on the mucosal immune system in the tissues of the gastrointestinal tract, the genital tract and the lungs, all of which play a role in transmission and progression of HIV disease.
The mucosal immune system improvs the adaptive anti-inflammatory defence to set homeostasis by immune exclusion mediated by secretory IgA antibodies to the clearance of pathogenic organisms from the mucosal surfaces by way of neutralising toxins and viral particles, inhibiting adherence of pathogens, colonisation and penetration of mucosal surfaces by pathogenic micro-organisms and immunosuppressive ways to limit over-reaction against inoffensive luminal antigens.
In 2008 he retired from full-time practice after 25 years to concentrate on his many years of clinical and research experience in the manipulation of the mucosal immune system.
The text examines the commonalities of the mucosal immune system and features detailed coverage of the major components of the gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems.
We are excited about commencing this study, which utilizes the mucosal immune system and thus offers significant potential to protect large numbers of individuals by administering enhanced flu vaccines.
Secondly, as discussed above, both CT and LT also bind with high affinity via their B-subunits to GM1 ganglioside receptors, which are present on most mammalian cells including not only epithelial cells, such as the "M cells" covering the Peyer's patches, but also all known antigen-presenting cells (APCs); this facilitates the uptake and presentation of the toxins to the gut mucosal immune system.
We have been able to validate experimentally some of the key events that take place in the regulation of the mucosal immune system when inflammatory bowel disease is triggered in mice," said Josep Bassaganya-Riera, associate professor of immunology at the Virginia Bioinformatics Institute, leader of the Nutritional Immunology and Molecular Medicine Group in the institute's CyberInfrastructure Division.