mucociliary

mu·co·cil·i·ar·y

(myū'kō-sil'ē-ā'rē),
Related to the interaction of mucus and ciliated epithelium.

mucociliary

/mu·co·cil·i·ary/ (mu″ko-sil´e-ar-e) pertaining to mucus and to the cilia of the epithelial cells in the airways.

mu·co·cil·i·ar·y

(myū'kō-sil'ē-ar-ē)
Pertaining to ciliated columnar epithelium found in the bronchial tree to the level of the terminal bronchioles, and in the uterine tubes.
See: ciliary

mucociliary

pertaining to a combination of cilia and mucus.

mucociliary blanket
a blanket of mucus overlying cilia beating in a watery sol on the surface of the respiratory mucosa.
mucociliary escalator
the nonimmunological defense mechanism involving ciliary action and flow of mucus from bronchioles, through the bronchi and trachea to the larynx, by which particulate matter is removed from the respiratory tract. Called also mucociliary ladder.
mucociliary ladder
see mucociliary escalator (above).
mucociliary transport
the effect of the operation of the mucociliary escalator.
References in periodicals archive ?
The data demonstrate that inhaled RPL554 activates CFTR, and stimulates an increase in ciliary beat frequency, thus having the potential to increase mucociliary clearance and as a consequence the ability to help to reinstate a central function impaired in this disease.
Accordingly, the current study aimed to explore the efficacy of EPs[R] 7630 in an infective bronchitis animal model, and on common symptoms associated with airways infection, cough and mucociliary clearance.
This case showed the spontaneous movement of a foreign body to the natural ostium of the maxillary sinus with the aid of mucociliary action.
Spyryx is developing inhaled peptides, which are designed to potently degrade ENaC, blocking this absorption and returning airway fluid volumes to normal levels, with the goal of restoring proper mucociliary clearance.
It modulates mucus production and viscosity and increases the motility of the mucociliary transport, improving expectoration.
The serpentine chrysotiles, because of their coiled, pliable nature, appear to impact more in the upper respiratory tract where they can be evacuated from the body via the mucociliary blanket.
Following the completion of the Phase 1 safety and tolerability study in CF patients, Pulmatrix plans to begin a Phase 1b clinical trial of PUR118 in CF patients evaluating mucociliary clearance velocity as an endpoint.
In cellular and animal models brevenal appears far more potent than existing drugs for CF and COPD and exhibits the unique quality of both suppressing inflammation and boosting mucociliary clearance.
Abnormal ion transport and defective mucociliary clearance are fundamental defects that contribute to complications of CF lung disease, including mucus plugging, chronic bacterial infection, inflammation and progressive airway damage," Accurso noted.
Miller continued, "Previous preclinical and exploratory clinical studies suggest that surfactant may improve mucociliary clearance, thereby potentially preventing further compromise of lung function.
Secondary to a failure in mucociliary defense mechanisms, recurrent pulmonary infections often leads to bronchiectasis seen in PCD patients.