Other approaches include drugs with antioxidant effects, drugs that facilitate lung regeneration, and mucoactive
agents for airway mucus hypersecretory diseases.
Sodium Bicarbonate - Sodium bicarbonate is a base that has occasionally been used as a mucoactive
There is little evidence supporting the use of mucoactive
agents such as N-acetylcysteine in AECOPD.
N-acetylcysteine supplementation may have the benefit of reducing the frequency of exacerbations and improving subjective symptoms (Weiss 2008) however has no effect as a mucoactive
agent at 600 mg twice daily (Stoller 2008).
Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive