pool of mucin

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pool of mucin

A nonspecific term for a mucinous “pool” seen by light microscopy in connective tissue in advancing age or in degenerative disease, in the peritoneum in a mucocele of the appendix or in protein-rich, lightly basophilic material admixed with adenocarcinoma cells in colorectal and breast colloid carcinomas.
References in periodicals archive ?
Two cases of MC (13%) had an almost exclusive colloid pattern, characterized by well-defined mucin lakes in which carcinoma cells were seen floating within the mucin but not clinging to the stroma (Figure 1).
Moreover, many GB MCs (5 of 15 [33%] in this study) shows prominent signet-ring cell formation not only in the mucin lakes but also infiltrating into the stroma as individual cells or cords ("poorly cohesive cell type" in the new World Health Organization classification).
How do mucin lakes extend beyond the muscularis propria?
There are case reports describing mucin pools extending to subserosa and submucosa, but no description of mucin lakes extending 14mm beyond the muscularis propria.
This cellularity of the mucin lakes poses questions on staging.
One more unusual observation from comparison of these two case reports: In first case study pre-chemoradiation MRI did not show obvious mucin lakes, but they became evident on post-chemoradiation MRI extending beyond the muscularis propria despite tumour mass having completely regressed.
In theses cases, the scant floating strips of malignant epithelium in mucin lakes are not always evident on a 2-dimensional tissue section, and deeper sections of areas of suspicion may uncover malignant glands (Figure 2, A and B).
Some malignant ducts were distended with mucin, and scattered small mucin lakes were present, some containing a few small groups of floating tumor cells (Figure 3).