moxifloxacin


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Related to moxifloxacin: Moxifloxacin hydrochloride

moxifloxacin

 [mok″sĭ-flok´sah-sin]
a broad-spectrum antibiotic effective against many gram-positive and gram-negative bacteria; administered orally as the hydrochloride salt in the treatment of bacterial complication of chronic bronchitis, acute sinusitis, community-acquired pneumonia, and skin and skin structure infections due to susceptible organisms.

moxifloxacin

/mox·i·flox·a·cin/ (-flok´sah-sin) a fluoroquinoloneantibacterial effective against many gram-positive and gram-negative bacteria; used as the hydrochloride salt.

moxifloxacin

(mŏk′sĭ-flŏk′sə-sĭn)
n.
An antibiotic drug of the fluoroquinolone class, C21H24FN3O4, used primarily to treat respiratory, sinus, and skin infections.

moxifloxacin

an antiinfective.
indications It is used to treat acute bacterial sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis; acute bacterial exacerbation of chronic bronchitis from S. pneumoniae, H. influenzae, H. parainfluenzae, Klebsiella pneumoniae, Staphylococcus aureus, and M. catarrhalis; and community-acquired pneumonia from S. pneumoniae, H. influenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae, and M. catarrhalis.
contraindication Known hypersensitivity to quinolones prohibits its use.
adverse effects Seizures are a life-threatening effect of this drug. Other adverse effects include prolonged QT interval, dizziness, fatigue, insomnia, depression, confusion, increased ALT and AST, flatulence, heartburn, oral candidiasis, dysphagia, pruritus, urticaria, photosensitivity, flushing, fever, chills, tremor, arthralgia, and tendon rupture. Common side effects include headache, restlessness, nausea, diarrhea, and rash.

moxifloxacin

A fluoroquinolone wide-spectrum antibiotic with activity against both Gram positive and Gram negative organisms. A brand name is Avelox.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

moxifloxacin

a fluoroquinolone antibiotic with activity against anaerobic bacteria.
References in periodicals archive ?
A companion study, SOLITAIRE-IV, is a phase III pivotal trial assessing the safety and efficacy of solithromycin when begun intravenously for treating community-ac quired pneumonia, followed by a switch to oral dosing, in comparison with intravenous followed by oral treatment with moxifloxacin.
The daily regimen consisted of ethambutol (800 mg), pyrazinamide (1,600 mg), prothionamide (500 mg), moxifloxacin (400 mg), and clofazimine (100 mg).
Having received the approval of American Food and Drug Administration (FDA) on Dec10, 1999, Moxifloxacin entered the US under the trade name of Avelox.
Widespread use of azithromycin and moxifloxacin will select for multidrug-resistant strains; the time for single-drug, one-dose regimens is probably over," said Dr.
Stepwise decrease in moxifloxacin susceptibility amongst clinical isolates of multidrug-resistant Mycobacterium tuberculosis: Correlation with ofloxacin susceptibility.
Moxifloxacin is a third-generation fluoroquinolone that has a wide spectrum, including gram-negative and gram-positive bacteria, anaerobes, and atypical pneumonia agents.
2 in the univariate analysis were included in a conditional multiple logistic regression model, as were the indicator variables for prior exposure to moxifloxacin and levofloxacin since these were the primary variables of interest.
Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial.
For example, preliminary testing is under way to determine if a fixed combination of moxifloxacin and dexamethasone might be more potent than ciprofloxacin/dexamethasone.
11) Moxifloxacin (MXF) is a fluoroquinolone with activities against both Gram positive and Gram negative bacteria.
Gelber, a physician at the University of California, San Francisco and his team treated 10 men with oral moxifloxacin daily for 2 months, followed by standard drugs for leprosy.