moxidectin


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moxidectin

(mok-sē-dek'tin),
An injectable macrocylic lactone antiparasitic used for control of Dirofilaria immitis heartworm and Ancylostoma caninum hookworms in heartworm-negative dogs; effect lasts 6 months; a semisynthetic avermectin class derivative of nemadectin isolated from Streptomyces cyaneogriseus subsp. noncyanogenus; less toxic in Collies then ivermectin; also used in horses as an oral gel and in cattle as topical solution; good especially for encysted small strongyles in horses. Mechanism of action is to enhance glutamate gate chloride channel permeabilty of membranes and increase gamma amino butyric acid at presynaptic membranes in nematode and arthropod nerve cells; leads to parasite paralysis and death. Not effective against flukes or tapeworms.

moxidectin

a macrolide derived from Streptomyces cyaneogriseus noncyanogenus with activity against nematodes and arthropods.
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7) Additional safe deworming protocols using ivermectin that have been reported include subcutaneous administration of ivermectin at 1 mg/kg followed by a second treatment at the same dose 1 week later, and a single oral administration of moxidectin at 200 pg/ kg; oral ivermectin administration was shown to be ineffective in controlling infections with S seurati in the Middle East.
Control trial and fecal egg count reduction test determinations of nematocidal efficacies of moxidectin and generic ivermectin in recently weaned, naturally infected calves.
Effect of moxidectin selection on the genetic variation within Cylicocyclus nassatus based on amplified fragment length polymorphism (AFLP).
Comparative efficacy evaluation of moxidectin and ivermectin injectable formulation against helminthes infestation of donkeys (Equus asinus) in Sudan.
The Committee concluded the referral procedure for veterinary medicinal products containing moxidectin to be administered to cattle, sheep and horses.
These endectocides with the active ingredient moxidectin offer persistent killing of internal parasites at multiple stages, including the most economically devastating parasite, Ostertagia ostertagi (brown stomach worm) and controls external parasites including lice, grubs and psoroptic mange mites on beef and dairy cattle.
Field efficacy of moxidectin 1 percent against Thelazia callipeda in naturally infected dogs.
A monthly topical application of 10% imidacloprid-1% moxidectin has been shown to decrease flea transmission [20].
It looked at 47 Welsh farms and the effectiveness of four types of wormer: Benzimidazole (1-BZ); Levamisole (2-LV); Ivermectin (3-ML) and Moxidectin (3-ML).
Some 94% of farms showed evidence of anthelmintic resistance to Benzimidazole, 68% to Levamisole, 51% to Ivermectin and 19% to Moxidectin.
20,21) The oral macrocyclic lactones, such as ivermectin, moxidectin, and others, provided effective chemoprophylaxis for heartworms in domestic dogs until recently.