By switching Ape on, researchers turned swelling mobs of mouse cancer
cells (above) back into normal intestinal tissue (below).
In mouse cancer
models, the combination of MCT-465, a dsRNA therapeutic, and MCT-475, an IgP therapeutic, not only induced the animal's immune system to eradicate the engrafted tumor, but upon rechallenge with tumor cells, no new tumors developed indicating the animal had developed protective anti-tumoral immunity.
Thus, in the present study, we use mouse cancer
cells to generate CT26 mouse colon cancer allograft before treating with oral DATS to examine whether or not DATS decreased the tumor size in vivo.
Companies commonly use Matrigel, a protein mixture secreted by mouse cancer
cells, but for that reason it can't be injected into patients.
The experiments behind these findings involved both mouse cancer
models and human cell cultures.
The breast cancer metastasis suppressor 1 (BRMS1) is a nuclear protein that regulates a number of genes, and suppresses metastasis without blocking growth in various human and mouse cancer
Karlyne Reilly, a principal investigator in the Mouse Cancer
Genetics Program at the National Cancer Institute, agrees.
Dorsey, PhD, RN, research fellow, Mouse Cancer
Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, MD
Under the microscope, the chromosomes in the mouse cancer
cells formed patterns similar to those seen in human cancer cells.
The researchers then remove these spleen cells and fuse them with mouse cancer
cells - harmless to humans - in a test tube.
The studies showed dose dependant efficacy of SDP-014 in two different mouse cancer
models, as judged by reduction in tumor burden, that were equal to or slightly better than the Taxotere(TM) formulation with similar, if not superior side effect profiles.
The scientific scope of this integrative human/mouse cancer
research program may be expanded through incorporation of individuals or groups with additional new perspectives and expertise, such as chemistry, computational and mathematical modeling, and systems biology, to create transdisciplinary approaches to the design, analysis, and applications of mouse cancer