Creation of the neural structure, unachievable by normal manufacturing techniques, begins by altering the behavior of kinesin motor proteins
-- biological machines found in every human cell.
Mutant SOD1 directly interferes with snapin, an essential molecule that adheres endosomes to dynein motor proteins
RNA-binding proteins (RBPs), kinesin motor proteins
, mRNAs and noncoding RNAs (ncRNAs) are involved in dendritic mRNA transport and translational regulation.
He now does research at the Yyldyz Laboratory at UC Berkeley and appeared on the cover of Science magazine in 2003 for his research on the movement of motor proteins
myosin motor proteins
which hydrolyze ATP (adenosine triphosphate), and thin actin filaments.
Specific topics include cell-receptor interactions, regulatory mechanisms of kinesin and myosin motor proteins
(inspiration of improved control of nanomachines), neuromechanics (the role of tension in neuronal growth and memory); roughness-induced superhydrophobicity, hierarchical carbon-based materials, nanotwinned hierarchical metals; in situ TEM electromechnical testing of nanowires and nanotubes, nano-cells for live-cell imaging of gene expression; and mechanics of curvilinear electronics, modeling and simulation of hierarchical protein materials, and multiscale modeling for the vascular transport of nanoparticles.
2012 Albert Lasker Basic Medical Research award--Michael Sheetz, 65, Columbia University, New York City; James Spudich, 70, Stanford University School of Medicine, Palo Alto, CA; and Ronald Vale, 53, University of California, San Francisco--"for opening up the study of cytoskeletal motor proteins
, whose activities are essential for numerous processes, such as muscle contraction, intracellular movement, and cell locomotion.
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins
Myosins are a family of ATP-dependent motor proteins
and are best known for their role in muscle contraction.
The experiment has confirmed the feasibility of a proposed delivery system to transport specific molecules using artificially synthesized DNAs and chemically energized motor proteins
, typically found in muscles and nerve cells, which are capable of moving autonomously by converting chemical energy into mechanical work.
The book will be useful for cell biologists examining the function of motor proteins
in a range of model organisms using both in vitro and in vivo techniques.
Myosins are a class of 40 motor proteins
that power cell movement and muscle contractions.