Srs2 is a helicase molecule - a motor protein
that's able to walk or slide along a strand of DNA and remove other proteins from DNA or separate the two strands of the twisted double helix.
In fact, even though the first motor protein
was discovered in 1864, scientists have only recently begun to understand just how these molecules work.
Using state of the art live-cell imaging techniques I will reveal also the molecular mechanism for signals localization and targeting driven by the motor protein
Brady says that the new study has shown that the short assemblies of amyloid activate a transport-regulatory enzyme called CK2, which causes the motor protein
to drop its cargo.
Cytokinetics' cardiovascular disease program is focused to cardiac myosin, a motor protein
essential to cardiac muscle contraction.
Her research focused on cytoplasmic dynein, a motor protein
that drives intracellular transport.
The Company's pipeline includes ARQ 087, designed to inhibit fibroblast growth factor receptor, ARQ 621, designed to inhibit the Eg5 kinesin motor protein
, and ARQ 736, designed to inhibit the RAF kinases.
Now, researchers have identified the mechanism by which a single amino acid change can disrupt the normal functioning of one of the critical components of that physiology-a molecular motor protein
called myo1c, which resides in the cochlea of the inner ear.
Further scans found that a motor protein
like those found in muscles piggybacked on GOLPH3.
Cardiac myosin is the cytoskeletal motor protein
in the cardiac muscle cell that is directly responsible for converting chemical energy into the mechanical force resulting in cardiac contraction.
The protocols detail methods relevant to each of the three molecular motor protein
superfamilies (kinesins, dyneins, and myosins), as well as motors that fall outside of these families (dynamins and F1ATPase).
A kinesin like calmodulin binding protein (KCBP) is a unique microtubule motor protein
originally discovered in flowering plants that contains two microtubule-binding sites, myosin tail homology, and a regulatory calcium/ calmodulin-binding domain.