motilin


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Related to motilin: secretin, Motilium

motilin

 [mo-til´in]
a polypeptide hormone secreted by enterochromaffin cells of the gut; it causes increased motility of several portions of the gut and stimulates pepsin secretion. Its release is stimulated by the presence of acid and fat in the duodenum.

mo·til·in

(mō-til'in), [MIM*158270]
A 22-amino acid polypeptide occurring in duodenal mucosa as a controller of normal gastrointestinal motor activity; in minute (that is, ng) doses, it induces powerful motor activity increases in the fundic gland area and antral pouches of the stomach, with an increase in pepsin output from the fundic gland.
[motility + -in]

motilin

/mo·til·in/ (mo-til´in) a polypeptide hormone secreted by enterochromaffin cells of the gut; it causes increased motility of several portions of the gut and stimulates pepsin secretion. Its release is stimulated by the presence of acid and fat in the duodenum.

motilin

[mōtil′in]
a peptide hormone secreted by enterochromaffin cells of the intestinal tract. It stimulates GI motility and pepsin secretion.

motilin

a polypeptide hormone secreted by enterochromaffin cells of the gut; it causes increased motility of several portions of the gut and stimulates pepsin secretion. Its release is stimulated by the presence of acid and fat in the duodenum.
References in periodicals archive ?
The presence of two different types of motilin receptors may account for the discrepancy in responses to a low or intermediate dose of erythromycin.
It has been shown that motilin and ghrelin have contractile activities in the gastrointestinal tract and their receptors are presented in the gastrointestinal tract of chickens (Kitazawa et al.
Furthermore, the postoperative plasma motilin and cholecystokinin levels were significantly higher than before surgery either in fasting or postprandial in dogs received continuous jejunal interposition (all p <0.
Further blood samples were taken before study commencement and after intervention to measure serum levels of gastrin, motilin and PP.
Pfizer will be responsible for all development, regulatory and commercial activities related to the motilin agonist program.
Infants with colic have higher motilin levels independent of how they are fed, suggesting this protein may 2play an important physiologic role in colic and other GI-related disorders among babies.
This suggests that motilin may have a role in colic.
Motilin regulates interdigestive gastric blood flow in dogs.
Erythromycin, the macrolide antibiotic, stimulates motilin receptors on the gastric antrum, inducing strong antral contractions.
4,6] Erythromycin causes gastrointestinal side effects primarily by its motilin agonist activity on smooth muscle receptors in the gut.
The Company's pipeline is derived from its proprietary MATCH[TM] technology and targets two validated GPCR drug targets, ghrelin and motilin.
The hormone motilin is secreted in ever increasing quantities by the fetus as gestation advances and most meconium discharges are said to occur in postdate gestations, because the motilin levels are highest then (8).