mosaicism


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Related to mosaicism: chimerism

mosaicism

 [mo-za´ĭ-sizm]
the presence in an individual of cells derived from the same zygote, but differing in chromosomal constitution.

mo·sa·i·cism

(mō-zā'i-sizm), [MIM*158250]
Condition of being mosaic (2).

mosaicism

/mo·sa·i·cism/ (mo-za´ĭ-sizm) in genetics, the presence in an individual of two or more cell lines that are karyotypically or genotypically distinct and are derived from a single zygote.

mosaicism

(mō-zā′ĭ-sĭz′əm)
n.
A condition in which tissues of genetically different types occur in the same organism.

mosaicism

[mōzā′isiz′əm]
Etymology: L, Musa, goddess of the arts
(in genetics) a condition in which an individual or an organism that develops from a single zygote has two or more cell populations that differ in genetic constitution. Most commonly seen in humans is a variation in the number of chromosomes in the cells, which may involve either a particular autosome, such as in Down syndrome, or the sex chromosomes, such as in Turner's syndrome and Kleinfelter's syndrome. See also mosaic, sex chromosome mosaic.

mosaicism

The phenotype of a multicelled organism, which is composed of cells expressing different genotypes; for instance, women are functionally mosaic due to the X chromosome genes expressed. Mosaicism due to mutation is less common.

mo·sa·i·cism

(mō-zā'i-sizm)
Condition of being mosaic (2).

mosaicism

The state in which two or more genetically different types of cell occur in the same individual. Although the cells are all derived from the same fertilized egg, they do not all possess the same number of chromosomes. In about 1% of cases of DOWN'S SYNDROME there are two different cell lines, one normal and the other with an additional chromosome 21 (trisomy 21). The effect of mosaicism varies with the proportion of cells containing abnormal chromosomes. Compare CHIMERA.

Mosaicism

A genetic condition resulting from a mutation, crossing over, or nondisjunction of chromosomes during cell division, causing a variation in the number of chromosomes in the cells.
Mentioned in: Patau Syndrome

mosaicism

the presence in an individual animal of cells derived from the same zygote, but differing in chromosomal constitution.
References in periodicals archive ?
These results indicate that the placenta does not shelter the embryo from polycyclic aromatic hydrocarbons and that embryonic development is a highly susceptible window for the induction of somatic mosaicism.
Prior reports differ in their estimates of the analytical sensitivity of PCR to detect large FMR1 expansions; some report sensitivity down to 1% mosaicism (15), others have reported difficulty in amplifying large alleles (17-18) or amplifying premutation alleles in a background of full mutations (19).
Trisomy 9 mosaicism in two girls with multiple congenital malformations and mental retardation.
A comparison of the frequencies of trisomy 21, mosaicism, and translocation DS of the current study with results of previous international studies was carried out.
Cornelia de Lange syndrome: Antenatal diagnosis in two consecutive pregnancies due to rare gonadal mosaicism of NIPBL gene mutation.
Gonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism.
Germinal mosaicism in a sample of families with Duchenne/Becker muscular dystrophy with partial deletions in the DMD gene.
In 95% of cases, the cause of DS is chromosomal aneuploidy, Trisomy 21, but rare cases of DS can arise from either chromosomal translocation or from mosaicism.
The cause of Meyerson phenomenon in PWS is not known despite several hypotheses, including a proinflammatory environment in the setting of ectatic postcapillary vessels (2, 5, 7) or possible genetic mosaicism underlying nevi (5).
Postzygotic mutation and germline mosaicism in the otopalatodigital syndrome spectrum disorders Eu J Hum Genet 2006.