mosaicism


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Related to mosaicism: chimerism

mosaicism

 [mo-za´ĭ-sizm]
the presence in an individual of cells derived from the same zygote, but differing in chromosomal constitution.

mo·sa·i·cism

(mō-zā'i-sizm), [MIM*158250]
Condition of being mosaic (2).

mosaicism

/mo·sa·i·cism/ (mo-za´ĭ-sizm) in genetics, the presence in an individual of two or more cell lines that are karyotypically or genotypically distinct and are derived from a single zygote.

mosaicism

(mō-zā′ĭ-sĭz′əm)
n.
A condition in which tissues of genetically different types occur in the same organism.

mosaicism

[mōzā′isiz′əm]
Etymology: L, Musa, goddess of the arts
(in genetics) a condition in which an individual or an organism that develops from a single zygote has two or more cell populations that differ in genetic constitution. Most commonly seen in humans is a variation in the number of chromosomes in the cells, which may involve either a particular autosome, such as in Down syndrome, or the sex chromosomes, such as in Turner's syndrome and Kleinfelter's syndrome. See also mosaic, sex chromosome mosaic.

mosaicism

The phenotype of a multicelled organism, which is composed of cells expressing different genotypes; for instance, women are functionally mosaic due to the X chromosome genes expressed. Mosaicism due to mutation is less common.

mo·sa·i·cism

(mō-zā'i-sizm)
Condition of being mosaic (2).

mosaicism

The state in which two or more genetically different types of cell occur in the same individual. Although the cells are all derived from the same fertilized egg, they do not all possess the same number of chromosomes. In about 1% of cases of DOWN'S SYNDROME there are two different cell lines, one normal and the other with an additional chromosome 21 (trisomy 21). The effect of mosaicism varies with the proportion of cells containing abnormal chromosomes. Compare CHIMERA.

Mosaicism

A genetic condition resulting from a mutation, crossing over, or nondisjunction of chromosomes during cell division, causing a variation in the number of chromosomes in the cells.
Mentioned in: Patau Syndrome

mosaicism

the presence in an individual animal of cells derived from the same zygote, but differing in chromosomal constitution.
References in periodicals archive ?
Clinical and gonadal features and early surgical management of 45,X/46,XY and 45,X/47,XYY chromosomal mosaicism presenting with genital anomalies.
Distributive conjugal transfer in mycobacteria generates progeny with meiotic-like genome-wide mosaicism, allowing mapping of a mating identity locus.
Fetal aneuploidy screening by maternal plasma DNA sequencing: 'false positive' due to confined placental mosaicism.
Increasing this analysis to 70 blood lymphocyte metaphases identified a low level of mosaicism with two cells showing a loss of the ring 9 (resulting in monosomy for chromosome 9), one cell with a broken ring 9, and one cell with a double ring resulting in trisomy for chromosome 9 (Figure 2).
Erin's sister Neve is one of only a handful of children in the world who have Ring 18 Mosaicism.
Smith FJ, Morley SM, McLean WH: Novel mechanism of revertant mosaicism in Dowling-Meara epidermolysis buuosa simplex.
Alternatively, in case of somatic mosaicism covering Hensen's node, which determines Nodal flow and lateralization during early embryogenesis (58, 59), it is possible that heterotaxy syndrome develops without mutations detectable in blood or heart tissue.
Angioma serpiginosum arranged in a systematized segmental pattern suggesting mosaicism.
Of the 29 specimens, from which we obtained high-quality chromosome preparations, one female presented mosaicism.
Chimerism, Mosaicism and the Cultural Construction of Kinship," Sexualities vol.
Fetal mosaicism, non-mosaic placenta--fetus has a mixture of normal and abnormal cells, placenta has only abnormal cells