morphogen


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mor·pho·gen

(mōr'fō-jen),
A soluble molecule secreted at a distance from the target cells that specifies the fates of cells. A morphogen may specify more than one cell type by forming a concentration gradient.

morphogen

/mor·pho·gen/ (mor´fah-jen) a substance in embryonic tissue that forms a concentration gradient and influences morphogenesis.

morphogen

(môr′fō-jĕn′)
n.
Any of various chemicals in embryonic tissue that influence the movement and organization of cells during morphogenesis by forming a concentration gradient.

morphogen

[môr′fəjen]
1 a soluble substance that controls the embryonic differentiation of a cell or tissue.
2 a substance secreted by one group of cells that causes a specific change in the growth and differentiation of a different group.

morphogen

(1) Any substance (e.g., retinoic acid) that triggers growth, proliferation and differentiation of cells and tissues in a concentration-dependent fashion. 
(2) Any molecule that orchestrates the development of an organism from the stage of a single cell to early embryogenesis.
References in periodicals archive ?
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.
But some biologists have raised questions about the theory, which contends that physical features are necessarily tied to absolute concentrations of proteins within the morphogen gradient.
The researchers have thought that these so-called morphogens create chemical maps by simply diffusing through an embryo.
Figure 6 illustrates a sink variant of the gradient model, where responding cells have two thresholds of sensitivity to morphogen concentration.
Equally amazing, says Tabin, is that the morphogen genes are used to trigger embryonic development in many different species.
patent 6,936,582, entitled "Synergistic Effects of OP/BMP Morphogens and GDNF/NGF Neurotrophic Factors.
My goal is to consolidate a world-class morphogen signal transduction laboratory, deciphering fundamental biological insights.
This may decrease the required dose of the morphogen due to its prolonged local retention time at application site (12), (13).
Retinoic acid is an important morphogen required as a signal for normal cardiovascular development; it promotes ventricular specification and maturation in cardiac stem cells and if present in an unregulated fashion, will lead to abnormal Development (Xavier-Neto et al.
Even though the current view is that a morphogen gradient drives the spatial arrangement of Bra expression, the precise mechanisms controlling timing and coordination of cells remain to be elucidated.
It is also possible that the fish mucus stimulus used in this study contains an unidentified morphogen that may induce cloning in some larvae and be manifested by slower growth and developmental rate in other larvae.
Thus, Sundaresan began searching for a substance in Arabadopsis that might be acting as a morphogen.