These data provide rationale for Rgenix's ongoing Phase 1a/b trial of RGX-104 in advanced cancer patients and support evaluation of RGX-104 as both a monotherapy
as well as in combination with CPIs.
Biopharmaceutical company UCB reported on Thursday the receipt of approval from the US Food and Drug Administration (FDA) for its supplemental new drug application (sNDA) for BRIVIACT (brivaracetam) CV monotherapy
indication for partial-onset (focal) seizures (POS) in patients 16 years and older with epilepsy.
ORAL Strategy is a bold study that directly compared XELJANZ as a monotherapy
or in combination with methotrexate to Humira in combination with methotrexate, said Michael Corbo, Chief Development Officer, Inflammation & Immunology, Pfizer Global Product Development.
001), compared with its monotherapy
components and placebo, according to AstraZeneca's statement.
Maruthur and her associates conducted an update of a previous systematic literature review and meta-analysis to assess the comparative effectiveness and safety of metformin monotherapy
and combination therapies including metformin with nonmetformin monotherapies in patients with type 2 diabetes.
The most common adverse event was fever, experienced by 53% of patients in the combination arm and 21% of patients in the monotherapy
arm; however, there were more grade 3 and 4 adverse events noted among patients treated with vemurafenib alone.
In the PREMIER trial, the addition of adalimumab to MTX therapy proved more effective than switching to adalimumab monotherapy
for all measures of response, including radiographic progression.
2% of the tocilizumab monotherapy
group achieving remission by week 8.
However, an ACE-I combined with an ARB increases the risk of renal complications and death more than monotherapy
(SOR: A, RCT).
The majority of the women (504) were on AED monotherapy
As a result, they were virtually being treated with protease-inhibitor monotherapy
Clarithromycin has been administered successfully as monotherapy
, and our case confirms these data.