Among the companies present was Roche Vitamins, which promoted the use of Stay-C 50, the sodium salt of the monophosphate
ester of ascorbic acid or trisodium ascorbyl phosphate.
Positive control cells were exposed to 100 [micro]M of 8-bromo-cyclic adenosine monophosphate
(8Br-cAMP) dissolved in medium containing 0.
As part of the collaboration, a HepDirect prodrug of a Roche proprietary nucleoside monophosphate
was identified and evaluated in various pre-clinical studies conducted by scientists at Metabasis and Roche.
Viadine is also designed to inhibit the production of phosphodiesterase type 5 (PDE5), which aids in the release of cyclic guanosine monophosphate
(cGMP) to relax the smooth muscles in the penis.
While it is true that caffeine is an adenosine receptor antagonist, it also increases cyclic adenosine monophosphate
, (cAMP) which has antiproliferative and immunosuppressive effects.
Intracellularly, MP is converted by hypoxanthine guanine phosphorybosyltransferase into thioinosine monophosphate
(TIMP) and subsequently into thioguanosine monophosphate
by a two-step process involving inosine monophosphate
dehydrogenase and guanosine monophosphate
About a decade ago, Tsien targeted cyclic adenosine monophosphate
(cAMP), a key molecule that can activate enzymes in a cell or its nucleus.
OB) and the Cancer Therapy & Research Center at The University of Texas Health Science Center in San Antonio, (CTRC at UTHSCSA) announced that the CTRC's Institute for Drug Development will collaborate on early phase studies of OncoVista's OVI-117, an L-nucleoside conjugate of 5-fluorodeoxyuridine monophosphate
(FdUMP), an analog of 5-FU, in various solid tumor cancer indications.
Otezla is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate
Structure-activity relationships for inhibition of inosine monophosphate
dehydrogenase by nuclear variants of mycophenolic acid.
Hypoxanthine is a breakdown product of the common cellular chemical adenosine monophosphate
, or AMP.
Adenosine 5' monophosphate
(AMP)-activated Protein Kinase (AMPK) Activators - I