monoclonal immunoglobulin

(redirected from monoclonal protein)

mon·o·clo·nal im·mu·no·glob·u·lin

a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type.
Synonym(s): M protein (2) , monoclonal protein, paraprotein (2)

monoclonal immunoglobulin

M spike, M spot, myeloma component, myeloma protein A protein produced by clonally expanded immunoglobulin-producing cells seen in various malignancies–eg, myeloma, Waldenström's disease, CLL, and other lymphoproliferative disorders; MI production may occur in other malignancies–eg, bladder, cervix, liver CAs, angiosarcoma, KS Nonmalignant monoclonal conditions Infections–eg,.Acanthocheilonema perstans, Endolimax nana, Entamoeba hartmanni, filariasis, schistosomiasis, septicemia, syphilis, trichuriasis, TB, viral hepatitis, hematologic disorders–eg, anemia, autoimmune hemolytic anemia, hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridoma.

mon·o·clo·nal im·mu·no·glob·u·lin

(mon'ō-klōn'ăl im'yū-nō-glob'yū-lin)
A homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells that; during electrophoresis of serum, appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass, and light chains of a single type.
Synonym(s): paraprotein (2) .
References in periodicals archive ?
1 - Delivery of reagents with the lease system for electrophoretic separation and detection of monoclonal protein by immunofixation.
Immunofixation electrophoresis was not ordered at that time, but it was previously performed at another institution and was positive for IgG monoclonal protein.
of an abnormal antibody known as a monoclonal protein.
0 mg/dL, total IgG decreased from 1722 mg/dL to 247 mg/dL and monoclonal protein concentration decreased from 1.
The rationale for emphasizing the need for the 24-hour urine protein electrophorsis in following patients with light chain myeloma is that there is a poor correlation between the serum FLC and the urinary monoclonal protein as measured by urine PEL (3) and for patients with amyloidosis, serial 24-hour urine measurements are critical for monitoring the status of a patient's nephrotic syndrome.
Interestingly, monoclonal protein disappeared after the treatment with steroids in our patient.
The editors (of the Institute of Haemotology, Royal Prince Alfred Hospital, Australia) present 23 chapters that provide step-by-step instructions on "classic and proven" laboratory methodologies for the investigation of multiple myeloma, a B-cell neoplasm in which malignant plasma cells accumulate in the bone marrow and produce lytic bone lesions and excessive amounts of a monoclonal protein.
In two of these three patients their disease had not progressed on treatment, based on several criteria including the monoclonal protein, and was considered stable at week 3 and week 6, the end of the dosing regimen.
However, subsequent serum protein immunotyping (Capillarys Immunotyping) failed to demonstrate a monoclonal protein.

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