monoclonal immunoglobulin


Also found in: Acronyms.

mon·o·clo·nal im·mu·no·glob·u·lin

a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type.
Synonym(s): M protein (2) , monoclonal protein, paraprotein (2)

monoclonal immunoglobulin

M spike, M spot, myeloma component, myeloma protein A protein produced by clonally expanded immunoglobulin-producing cells seen in various malignancies–eg, myeloma, Waldenström's disease, CLL, and other lymphoproliferative disorders; MI production may occur in other malignancies–eg, bladder, cervix, liver CAs, angiosarcoma, KS Nonmalignant monoclonal conditions Infections–eg,.Acanthocheilonema perstans, Endolimax nana, Entamoeba hartmanni, filariasis, schistosomiasis, septicemia, syphilis, trichuriasis, TB, viral hepatitis, hematologic disorders–eg, anemia, autoimmune hemolytic anemia, hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridoma.

mon·o·clo·nal im·mu·no·glob·u·lin

(mon'ō-klōn'ăl im'yū-nō-glob'yū-lin)
A homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells that; during electrophoresis of serum, appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass, and light chains of a single type.
Synonym(s): paraprotein (2) .
References in periodicals archive ?
Amyloid subtyping usually reveals monoclonal immunoglobulin light chains.
There are no official guidelines for the optimal approach to screening patients for the presence of an abnormal monoclonal immunoglobulin, but a consensus has developed that a combination of tests is probably needed (3).
Influence of monoclonal immunoglobulins in direct determinations of iron in serum.
Monoclonal immunoglobulin deposition diseases (MIDD) include primary and light chain deposition disease.
A sampling of topics in the following chapters: infection-related glomerulonephritis; discover of genes related to diabetic nephropathy in various animal models; glomerular basement membrane disorders in experimental models; lupus nephritis; monoclonal immunoglobulin light and heavy chain deposition diseases; HIV-associated nephropathy; some contrarian evidence in renal vasculature in essential hypertension; and glomerular repair--present status and future expectations.
In extramedullary plasmacytoma, immunohistochemical staining of tissue biopsies shows monoclonal immunoglobulin.
The 2008 World Health Organization criteria for classification of hematologic diseases characterizes Waldenstrom macroglobulinemia (WM) as a subset of LPL that has a detectable level of monoclonal immunoglobulin (Ig) M gammopathy, with bone marrow involvement by LPL.
The article, entitled "A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin," is the result of collaborative efforts between the Wadsworth Center of the New York State Department of Health (Albany, NY) and Soligenix.
Monitoring plasma cell proliferative diseases such as multiple myeloma (MM) [3] is usually straightforward, since the monoclonal immunoglobulin in most cases can be identified and quantified as an M-spike on serum protein electrophoresis (1-3).
One of the first observations was that unlike amyloid, nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component.
Multiple myeloma is a hematologic malignancy characterized by proliferation of a neoplastic plasma cell population that usually leads to abundant production of a monoclonal immunoglobulin, also called paraprotein or M-protein, as well as decreased concentrations of normal polyclonal immunoglobulins.
Clonal expansion of the tumor cells produces a monoclonal immunoglobulin, which can be quantified as a direct biomarker of disease burden.

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