monoclonal gammopathy of undetermined significance


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monoclonal gammopathy of undetermined significance

a paraproteinemia (an abnormal gammaglobulin, typically with λ light chain component) of less than 3 g/100 mL, which, at the time of discovery, is without apparent cause; specifically, there is no evidence of multiple myeloma or other malignant disorders.

monoclonal gammopathy of undetermined significance

Benign monoclonal gammopathy, MGUS Hematology A condition defined by lab criteria Criteria Normal Hb, serum albumin < 20 g/L–US: < 2 g/dl, an M-component, no Bence-Jones proteinuria, < 5% plasma cells in the BM, no osteolytic lesions; MGUS differs from myeloma in that the plasma cells in the BM are < 20%, and the ESR and monoclonal component are lower Prognosis 20-40% of MGUS progress to malignant monoclonality Management Plasma exchange may be improve the neuropathy associated with IgA or IgG MGUS

monoclonal gammopathy of undetermined significance

A condition featuring the presence of a monoclonal protein in people with no evidence, for a period of years, of clinical indications of multiple myeloma or other related disorders. In a proportion of cases, however, a malignant plasma cell disease develops.

Monoclonal gammopathy of undetermined significance (MGUS)

Common condition in which M-protein is present, but there are no tumors or other symptoms of disease.
Mentioned in: Multiple Myeloma

Patient discussion about monoclonal gammopathy of undetermined significance

Q. Does anyone know anything about MGUS?

A. MGUS is a condition that affects a type of white blood cell known as a plasma cell. Plasma cells are a type of white blood cell that produce special proteins, known as antibodies or immunoglobulins. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical.

More discussions about monoclonal gammopathy of undetermined significance
References in periodicals archive ?
A long-term study of prognosis in monoclonal gammopathy of undetermined significance.
Molecular characterization of heavy chain immunoglobulin gene rearrangements in Waldenstrom's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.
Patients often have varying combinations of periocular xanthogranuloma and other blood dyscrasias including thrombocytopenia, paraproteinemia and/or monoclonal gammopathy of undetermined significance.
Crystal-storing histiocytosis (CSH) is a rare manifestation associated with disorders that express monoclonal immunoglobulins, such as multiple myeloma, monoclonal gammopathy of undetermined significance, and lymphoid disorders such as lymphoplasmacytic lymphoma.
Information about serum FLC measurement in nonsecretory myeloma, monoclonal light chain diseases, and reference populations is reported in the literature (1-5,7), but there is limited data about FLCs in renal disease, monoclonal gammopathy of undetermined significance (MGUS), and myeloma patients after autologous stem cell transplants.
Monoclonal gammopathy of undetermined significance,Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment.
The monoclonal gammopathies include multiple myeloma (MM), [3] light-chain myeloma, Waldenstrom macroglobulinemia, nonsecretory myeloma (NSMM), smoldering multiple myeloma, monoclonal gammopathy of undetermined significance, primary systemic amyloidosis (AL), and light-chain-deposition disease (LCDD) (2).
The diagnoses of sarcoidosis and monoclonal gammopathy of undetermined significance (MGUS) were established.
We and others have previously demonstrated that biochemical markers of bone resorption are markedly higher in MM patients than in patients with monoclonal gammopathy of undetermined significance (MGUS) or in patients with benign OPO (8-12).
It is important to note that many monoclonal gammopathies identified on serum electrophoresis are benign, so-called monoclonal gammopathy of undetermined significance (MGUS).

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