monoclonal antibody therapy


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monoclonal antibody therapy

The use of monoclonal antibodies to suppress immune function, kill target cells, or treat specific inflammatory diseases. Because of their high level of specificity, they bind to precise cellular or molecular targets. A potential problem associated with the use of monoclonal antibodies is an allergic reaction to the foreign antigens in the antibody, since they are created from mouse cells. Monoclonal antibodies have numerous uses in health care. See: table; hybridoma; monoclonal antibody
Name of AntibodyCondition Treated or Prevented
AdalimumabRheumatoid arthritis; psoriasis
BevacizumabSolid tumors
EdrecolomabSolid tumors
EfalizumabPsoriasis
EnlimomabOrgan transplant rejection
IbritumomabFollicular lymphoma
InfliximabCrohn's disease; rheumatoid arthritis
NatalizumabRelapsing forms of multiple sclerosis
OmalizumabAllergic rhinitis
OKT3Organ transplant rejection
PalivizumabRespiratory syncytial virus
RituximabLeukemias and lymphomas
RhuMAb/VEGFSolid tumors
TositumomabB cell lymphoma
TranstuzumabMetastatic breast cancer
References in periodicals archive ?
Nexvet's pipeline product ranevetmab, a mAb targeting nerve-growth factor for treatment of chronic pain associated with osteoarthritis in dogs, would, upon approval, be the companion animal industry's first monoclonal antibody therapy administered monthly by injection for chronic pain.
2,3 Erenumab is the first fully human monoclonal antibody therapy specifically designed to target and block the Calcitonin Gene-Related Peptide (CGRP) receptor, believed to play a critical role in mediating the incapacitating pain of migraine.
M2 PHARMA-April 11, 2017-US FDA Grants Orphan Drug Designation for NantCell's Ganitumab Monoclonal Antibody Therapy in Ewing Sarcoma
Filings: XBiotech has been granted Fast Track Designation for its novel True Human monoclonal antibody therapy intended to treat all forms of Staphylococcus aureus infections, including Methicillin-resistant S.
Aratana Therapeutics has a full license from USDA for its monoclonal antibody therapy called AT-004, intended for dogs with B-cell lymphoma.
Washington, September 2 ( ANI ): A monoclonal antibody therapy developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).
This pocket guide aimed at oncologists, physicians, and nurses offers information in a bulleted format on diagnosis, surgery, and radiotherapeutic and chemotherapeutic treatment of breast cancer, including staging, monoclonal antibody therapy, genetic aspects, and prevention.
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.
Managing drug infusion reactions: Focus on cetuximab monoclonal antibody therapy.
It is controversial in that it is very expensive; it is only used in patients who have early HER2-positive disease; it has side-effects; and the long-term effects of monoclonal antibody therapy are not known.
The scientific article, "CD32B, the Human Inhibitory Fc Receptor IIB, as a Target for Monoclonal Antibody Therapy of B-Cell Lymphoma," appears in the October 2006 issue of Blood, the journal of the American Society of Hematology.
There is potential for a better overall response when these agents are combined with monoclonal antibody therapy (e.

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