monocarboxylate transporters

monocarboxylate transporters

transmembrane carrier molecules, co-transporting monocarboxylic acid anions (typically lactate) and protons (H+) through cell membranes, notably those of skeletal and cardiac muscle fibres. Considered to be responsible for the major part of lactate transport at low concentrations but, as saturation of the carrier approaches, simple diffusion (which is primarily of the undissociated lactic acid) becomes more important. See also lactate, lactic acid.
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Two types, monocarboxylate transporters and sodium coupled monocarboxylate transporters, are also located on brain neurons, astrocytes (Vijay, 2014), microglia (Moreira, 2009), oligodendrocytes (Lee, 2012), and the endothelia of the blood-brain barrier (Bergesen, 2002).
Role of monocarboxylate transporters in drug delivery to the brain.
Monocarboxylate transporters and heat shock proteins in domestic pigs in relation to stress and meat quality [dissertation].
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
The major transporter molecules of lactate in cells are monocarboxylate transporters (MCTs).
Meredith, "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond," Pflugers Archiv, vol.
Moreover, the detection of the presence of the MCT1 mitochondrial isoform in the plasma membrane and of intra-mitochondrial lactate dehydrogenase enzyme (intramitochondrial LDH) (12,13) led to a new interpretation of the monocarboxylate transporters where cytosolic lactate could be captured and re-oxidized in the mitochondria within the same cell (6).
Monocarboxylate transporters in subsarcolemmal and intermyofibrilar mitochondria.
Monocarboxylate transporters play important role in the maintenance of the glycolytic metabolism through proton linked transport of monocarboxylic acid [60] (Figure 2).
Further, monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate [60].
They found that CAFs can remove lactate from the tumor environment and utilize it as an energy source by increased activity of monocarboxylate transporters.