monobactam


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mon·o·bac·tam

(mon'ō-bak'tam),
A class of antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams; for example, aztreonam.

monobactam

/mon·o·bac·tam/ (-bak´tam)
1. a class of synthetic antibiotics with a cyclic beta-lactam nucleus.
2. a class of synthetic antibiotics having a monocyclic β nucleus.

mon·o·bac·tam

(mon'ō-bak'tam)
Antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams.

mon·o·bac·tam

(mon'ō-bak'tam)
Class of antibiotic with a monocyclic β-lactam nucleus: structurally different from other β-lactams.

monobactam

a group of monocyclic β-lactamase resistant antibiotics which includes aztreonam and carumonam sodium.
References in periodicals archive ?
Antimicrobial drug MICs for Acinetobacter genomospecies 15TU isolates from cows and reference strains, France, August 2010 * MIC, [micro]g/mL Acinetobacter genomospecies 15TU Drug class BY1 BY2-BY9 Penicillins and combinations Amoxicillin >256 128-256 Amoxicillin + CLA >256 128-256 Cephalosporins Cefoxitin 32 16-32 Cefotaxime 32 16-32 Ceftazidime 32 16-32 Cefepime 16 4-16 Monobactam (aztreonam) 64 32 Carbapenems Meropenem 16 2-4 Imipenem >32 4-6 Doripenem 8 2-4 Cyclines Tetracycline >256 >256 Tigecycline 0.
Aztreonam was approved in December 1986 by the FDA as a monobactam, a synthetic bactericidal antibiotic.
Studies of an inhaled formulation of the monobactam antibiotic aztreonam in patients with cystic fibrosis show that it is a safe and effective treatment for Pseudomonas aeruginosa lung infections in this population, a federal advisory panel concluded in a 15-2 vote.
Aztreonam is a monobactam antibiotic that contains a betalactam ring.
7 Approved/marketed carbapenems and one monobactam (Aztreonam), which exert their bactericidal effects through the inhibition of cell wall synthesis (Source: Biopharm Reports, 2013).
1) Historically, most members of the family were susceptible to a wide spectrum of antibiotics, including broad-spectrum cephalosporins and penicillins, monobactam, and carbapenem antibiotics.
These molecules have versatile hydrolytic capacities that inactivate antibiotics in the penicillin, cephalosporin, monobactam, and carbapenem families.
ESBL producing Enterobacteriaceae are, as a rule, resistant to all cephalosporins and extended spectrum penicillins including the monobactam, aztreonam, while resistance to trimethoprim--sulphamethaxazole and aminoglycosides is frequently co-transferred on the same plasmid.
2-]), are resistant to inhibition by clavulanic acid, sulbactam and tazobactam, are inhibited by chelating agents, and do not hydrolyze monobactam like aztreonam (3).
Five additional antibiotic-resistant genes identified, including cephalosporin, monobactam, penicillin and streptomycin --
CORUS Pharma, who recently completed a Series C Round of financing, has licensed customised eFlow products for two clinical programs including inhaled aztreonam (a monobactam antibiotic) for cystic fibrosis and inhaled lidocaine for asthma.
CORUS Pharma, who recently completed a Series C Round of financing, has licensed customized eFlow products for two clinical programs including inhaled aztreonam (a monobactam antibiotic) for cystic fibrosis and inhaled lidocaine for asthma.