monobactam


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mon·o·bac·tam

(mon'ō-bak'tam),
A class of antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams; for example, aztreonam.

monobactam

/mon·o·bac·tam/ (-bak´tam)
1. a class of synthetic antibiotics with a cyclic beta-lactam nucleus.
2. a class of synthetic antibiotics having a monocyclic β nucleus.

mon·o·bac·tam

(mon'ō-bak'tam)
Antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams.

mon·o·bac·tam

(mon'ō-bak'tam)
Class of antibiotic with a monocyclic β-lactam nucleus: structurally different from other β-lactams.

monobactam

a group of monocyclic β-lactamase resistant antibiotics which includes aztreonam and carumonam sodium.
References in periodicals archive ?
If the isolate is confirmed ESBL positive, it should be reported resistant to all penicillins, cephalosporins (except for cephamycines) and monobactam irrespective of in vitro sensitivity.
To detect extended spectrum [beta]-lactamases (ESBL) strains which hidrolyzed 3a generation cephalosporins (Cftx, ceftazidime Caz 30 [micro]g) as well as the monobactam aztreonam (Azt 30 [micro]g) and those inhibited by CAM but not by cefoxitin (Fox 30 [micro]g) were observed; boronic acid discs (Bor) were also used because its hability to inhibit plasmidic AmpC serin [beta]-lactamases (AmpCp) with 3[degrees] generation Cfp as indicators (17).
beta]-Lactam antibiotics are frequently used for Agrobacterium eradication in plant tissues, they are penicillin, cephalosporin, cephamycin, oxacephem, monobactam and carbapenem, and are currently being developed to improve and enlarge antibacterial activity (Demain and Elander, 1999).
carbapenem resistance (with both E-tests and the VITEK II analyser), susceptibility to the monobactam aztreonam, and synergy between ethylenediaminetetra-acetic acid (EDTA) and the carbapenems, the production of a metallo-beta-lactamase (MBL) was suspected.
No se debe utilizar ninguna cefalosporina, monobactam ni penicilina con inhibidores de las betalactamasas aunque se informe sensibilidad, debido a la seleccion de aislados con CIM elevadas por el efecto inoculo (33, 35-39).
As with other New Delhi metallo-[beta]-lactamase (NDM-1)-producing strains, the isolate was resistant to carbapenems and susceptible to aztreonam, a monobactam.
Aztreonam was approved in December 1986 by the FDA as a monobactam, a synthetic bactericidal antibiotic.
Studies of an inhaled formulation of the monobactam antibiotic aztreonam in patients with cystic fibrosis show that it is a safe and effective treatment for Pseudomonas aeruginosa lung infections in this population, a federal advisory panel concluded in a 15-2 vote.
Aztreonam is an agent of the monobactam class of drugs.
5mg/500ml), ceftriazone (1 mg/500ml), and oxymino monobactam aztreonam (1 mg/500ml) and one antifungal fluconazole (5 mg/500ml) were used to avoid the contamination.
1) Historically, most members of the family were susceptible to a wide spectrum of antibiotics, including broad-spectrum cephalosporins and penicillins, monobactam, and carbapenem antibiotics.
Antimicrobial drug MICs for Acinetobacter genomospecies 15TU isolates from cows and reference strains, France, August 2010 * MIC, [micro]g/mL Acinetobacter genomospecies 15TU Drug class BY1 BY2-BY9 Penicillins and combinations Amoxicillin >256 128-256 Amoxicillin + CLA >256 128-256 Cephalosporins Cefoxitin 32 16-32 Cefotaxime 32 16-32 Ceftazidime 32 16-32 Cefepime 16 4-16 Monobactam (aztreonam) 64 32 Carbapenems Meropenem 16 2-4 Imipenem >32 4-6 Doripenem 8 2-4 Cyclines Tetracycline >256 >256 Tigecycline 0.