monoamine

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monoamine

 [mon″o-am´ēn]
an amine containing only one amino group.
monoamine oxidase (MAO) a copper-containing enzyme that deaminates monoamines such as dopamine, epinephrine, norepinephrine, and serotonin. See also monoamine oxidase inhibitor.

mon·o·am·ine

(mon'ō-am'ēn, -in), Although this word is correctly stressed on the second-last syllable, U.S. usage often stresses it on the last syllable.
A molecule containing one amine group.
Synonym(s): monamine

monoamine

/mono·amine/ (mon″o-ah-mēn´) an amine containing one amino group, e.g., serotonin, dopamine, epinephrine, and norepinephrine.

monoamine

(mŏn′ō-ăm′ēn, -ə-mēn′)
n.
An amine compound containing one amino group, especially a compound that functions as a neurotransmitter.

monoamine

[mon′ō·am′in]
an amine containing one amine group.

monoamine

A class of molecules that contain one amino group connected to an aromatic ring by a two-carbon chain. The physiologically important monoamines derive from aromatic amino acids—phenylalanine, tyrosine, tryptophan—and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes. They include neurotransmitters and neuromodulators, in particular catecholamines (dopamine, epinephrine and norepinephrine) and tryptamines (serotonin and melatonin).

monoamine

Pharmacology A class of hormones or neurotransmitters–eg, catecholamines–dopamine, epinephrine, norepinephrine and indoleamines–serotonin, melatonin, which have 1 amine. See Catecholamine.

mon·o·am·ine

, monamine (mon'ō-ǎ-mēn', mon-amin)
A molecule containing one amine group.

monoamine

an amine containing only one amino group.

monoamine oxidase
a cuproprotein enzyme that deaminates monoamines such as serotonin, epinephrine, norepinephrine, dopamine, tyramine and tryptamine. Called also MAO.
monoamine oxidase inhibitors
substances that inhibit the activity of monoamine oxidase, increasing catecholamine and serotonin levels in the brain; they are used as antidepressants and antihypertensives. Called also MAO inhibitors.
References in periodicals archive ?
Current antidepressant drug therapies include selective serotonin reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors and the older, less specific monoamine regulating drugs.
A single dose of VW was selected for the estimation of brain monoamines, which was most appropriate according to the effects of VW on sleep architecture (200 mg/kg body weight).
Attempts can be made to either lower elevated levels of MAO-A with selected antagonist drugs, or to increase the concentration of monoamine neurotransmitters that can elevate mood.
Measurement of monoamine metabolites in CSF can therefore be used to establish a "snapshot" of serotonin and catecholamine metabolism at one particular time that may provide an indication of disease mechanisms that affect the neurotransmitter pathways.
For this purpose, we evaluated locomotor activity across the course of exposure, whereas monoamine levels in striatum, prefrontal cortex, nucleus accumbens, and hypothalamus and stereologic cell counts of TH-positive (T[H.
Pharmacologic treatments for depression have advanced greatly since the development of the first therapies, monoamine oxidase inhibitors (MAOIs).
Partial insomnia, hyperactivity and hyperdipsia induced by repeated administration of toluene in rats: Their relation to brain monoamine metabolism.
Thus, the present study was conducted to investigate the anxiolytic effects of Schisandra lignans extract (SLE) on restraint stress-induced anxiety mice using light-dark (L-D) test, and the influences on the levels of monoamines noradrenaline (NE), dopamine (DA) and serotonin (5-HT) in cerebral cortex of mice, as well as the plasma corticosterone (CORT) level.
The researchers then looked at the polymorphisms in genes that coded for two enzymes that regulate monoamine levels: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A).
In a monoamine-disruption test using 5 mg/kg (intraperitoneal) tranylcypromine (Tcy), a monoamine oxidase inhibitor, both BPA-treated and low-dose NP-treated offspring at 22-24 weeks of age failed to show a significant increment in locomotion in response to Tcy, whereas control and high-dose NP-treated offspring significantly increased locomotion behavior after Tcy injection.
Improved understanding of the molecular biology and activity of monoamine oxidases (MAOs) has provided new insights into the role of the enzymes in psychiatric illness and into the development of the next generation of neuropharmaco-logic compounds, said Lynn Wecker, PhD, chair of pharmacology and Therapeutics at the University of South Florida College of Medicine in Tampa.
Also, both types of the enzyme exist in many body tissues, including the liver and the wall of the ileum where they metabolize monoamines in the diet.