monoamine oxidase

Also found in: Dictionary, Thesaurus, Financial, Encyclopedia, Wikipedia.


an amine containing only one amino group.
monoamine oxidase (MAO) a copper-containing enzyme that deaminates monoamines such as dopamine, epinephrine, norepinephrine, and serotonin. See also monoamine oxidase inhibitor.

a·mine ox·i·dase

1. an oxidoreductase containing copper, and perhaps pyridoxal phosphate, and carrying out the same reaction as amine oxidase (flavin-containing). Synonym(s): diamine oxidase, histaminase
2. an oxidoreductase containing flavin and oxidizing amines with the aid of O2 and water to aldehydes or ketones with the release of NH3 and H2O2. Acted upon by antidepressants. Synonym(s): adrenaline oxidase, monoamine oxidase, tyraminase, tyramine oxidase

monoamine oxidase

n. Abbr. MAO
An enzyme that catalyzes the oxidative breakdown of monoamines such as norepinephrine and serotonin, thus regulating synaptic transmission of monoamine neurotransmitters in the nervous system.

monoamine oxidase (MAO)

an enzyme that catalyzes the oxidation of amines. See also monoamine oxidase inhibitor.

monoamine oxidase

MAO, one of a group of enzymes found in brain cells, in peripheral adrenergic and dopaminergic nerve endings and in the intestinal wall and liver. These enzymes play an important part in the breakdown of the neurotransmitters NORADRENALINE, DOPAMINE and serotonin (5-hydroxytryptamine). Non-selective inhibition of these enzymes will elevate mood. Selective MAO-A enzymes act on serotonin; selective MAO-B inhibitor drugs act on phenylethylamine in the glial cells of the brain and elsewhere. The selective MAO-A inhibitor drugs are used to treat DEPRESSION and anxiety; selective MAO-B inhibitors are used to treat Parkinsonism.

monoamine oxidase,

n an enzyme that catalyzes the oxidation of amines.
monoamine oxidase inhibitor (MAOI),
n an agent that blocks the oxidation and deamination of monoamines. The action of the inhibitor may increase the presence of catecholamines, which have antidepressant properties, but it is used for a range of disorders. It can include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). There are relative contraindications of the use of the drug with local anesthetic agents delivered in the dental office.


an amine containing only one amino group.

monoamine oxidase
a cuproprotein enzyme that deaminates monoamines such as serotonin, epinephrine, norepinephrine, dopamine, tyramine and tryptamine. Called also MAO.
monoamine oxidase inhibitors
substances that inhibit the activity of monoamine oxidase, increasing catecholamine and serotonin levels in the brain; they are used as antidepressants and antihypertensives. Called also MAO inhibitors.
References in periodicals archive ?
Combining stimulants and monoamine oxidase inhibitors: a reexamination of the literature and a report of a new treatment combination.
The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder.
The expression of KLF11 (TIEG2), a monoamine oxidase B transcriptional activator in the prefrontal cortex of human alcohol dependence.
Reduced platelet monoamine oxidase type B activity and lymphocyte muscarinic receptor binding in unmedicated children with attention deficit hyperactivity disorder," Biomarkers, vol.
Panchuk-Voloshina, "A one-step fluorometric method for the continuous measurement of monoamine oxidase activity," Analytical Biochemistry, vol.
Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase.
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.
1998) and is an inhibitor of monoamine oxidase B that activates MPTP neuorotoxicity (Yong and Perry 1986).
Monoamine oxidase inhibitors (MAOIs), another antidepressant, is less frequently used.
Criminal violence, for example, might be excused as a consequence of low levels of serotonin or monoamine oxidase in the brain.
Researchers looked at 17 trials of a group of drugs called monoamine oxidase type B inhibitors (MAOBIs), which are used to slow the progression of Parkinson's.
Researchers looked at 17 trials involving monoamine oxidase type B inhibitors, used to slow the progression of the disease.