monoacylglycerol lipase


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mon·o·ac·yl·glyc·er·ol li·pase

an enzyme that catalyzes the hydrolysis of monoacylglycerol to produce a fatty acid anion and glycerol; a part of lipid degradation.
References in periodicals archive ?
US-based pharmaceutical company Abide Therapeutics has started enrollment and dosing in a Phase 1 PET occupancy study with ABX-1431, a first-in-class investigational monoacylglycerol lipase inhibitor, and [18F] ABX-1488, a human MGLL-specific PET ligand, the company said.
2-AG is hydrolyzed into arachidonic acid and glycerol primarily by monoacylglycerol lipase (MGL), which was first cloned from mouse adipose tissue.
2007) Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus.
Lipolysis in adipocytes is regulated in a step-wise fashion by adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoacylglycerol lipase.
Washington, November 2 ( ANI ): A new study has identified an enzyme called Monoacylglycerol lipase (MAGL) as a potential therapeutic target to treat or prevent Alzheimer's disease.
Experts at The Scripps Research Institute identified the enzyme, called monoacylglycerol lipase (MAGL) as a key player responsible for the aggressive behaviour of cancer cells.