Importantly, the research team discovered that an enzyme called alpha/beta hydrolase domain-6 (in short ABHD6) breaks down monoacylglycerol
and thus negatively controls insulin release.
Scientists are investigating relationships between reduced interfacial surface tension and the percent of monoacylglycerol included in the oil phase in order to determine optimum levels of monoacylglycerol required for each type of formulation.
Efforts are focusing on 60% fat spreads, with a control or standard spread containing commercial soft margarine and distilled monoacylglycerols to serve as a reference for comparing the dairy-based spreads.
Under the three-year agreement, Abide and Oxford will explore the role of monoacylglycerol
lipase (MGLL) inhibitors in altering endocannabinoid tone in the human brain.
Washington, November 2 ( ANI ): A new study has identified an enzyme called Monoacylglycerol
lipase (MAGL) as a potential therapeutic target to treat or prevent Alzheimer's disease.
During digestion, the pancreatic lipase action specifically removes fatty acids at the 1,3 position while the resulting monoacylglycerol
molecule is efficiently incorporated into micelles (Lien, 1994), leading to preferential absorption of fatty acids at the 2 position of the glycerol backbone of triacylglycerols.
Pioneering innovative approaches to selectively target the serine hydrolase enzymes group with collaborators at UC San Diego, Abide has created novel small molecule inhibitors of its target enzyme, monoacylglycerol
lipase (MAGL) of the serine hydrolase family through the company's selective targeting technology.
Experts at The Scripps Research Institute identified the enzyme, called monoacylglycerol
lipase (MAGL) as a key player responsible for the aggressive behaviour of cancer cells.
The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol