molecular mimic

molecular mimic

A chemical compound that structurally or functionally resembles biomolecules and can recognise and bind the biomolecules’ targets.
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Resveratrol, a molecule found in red wine, has been touted as a molecular mimic of a calorie restricted diet, an intervention that has been shown to nearly double the lifespan of all forms of life when caloric intake is cut in half.
To better understand how the immune response causes these neurological changes, the researchers exposed pregnant mice to a synthetic molecular mimic of a replicating virus.
In this study, calorie restriction significantly differentiated (up or down-regulated) 198 genes, and resveratrol, its molecular mimic, significantly influenced 225 genes, while resveratrol-based matrix (Longevinex(R)) significantly differentiated 1711 genes.
BXT-50172 is a small molecular mimic of Glutathione peroxidase (GPx), an enzyme that may prevent excessive oxidation of lipids and consequent inflammation.
Glycomimetics--non-carbohydrate compounds that are molecular mimics of carbohydrates--are increasingly in demand as therapeutic agents.
So far, he adds, investigators have had little luck finding smaller molecular mimics of GDNF and artemin that could be taken as oral drugs.
It is an "anti-idiotypic" vaccine whereby the patient receives molecular mimics (peptides) of antibodies to the p53 protein.
It is an anti-idiotypic vaccine whereby the patient receives molecular mimics of the mutated p53 protein (peptides) to stimulate an immune response.
Walensky said that molecular mimics of these domains are showing great promise in early clinical trials, yet most of these drugs block three or more BCL-2 family proteins, rather than homing in on one specific cancer-causing target.
In the new study, researchers have shown how they had added molecular mimics of these host cell receptors onto the surface of harmless bacteria capable of surviving in the human gut.

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