molecular autopsy

molecular autopsy

A term of art for postmortem genetic testing in cases in which the cause of death is unascertained after a thorough autopsy. Molecular autopsies are especially important in sudden cardiac deaths, as a significant minority may be linked by genetic testing to inherited cardiac diseases, including arrhythmic disorders such as congenital long Q-T syndrome and Brugada syndrome, which can be appropriately managed if identified in vivo.
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ese drew a blank as did biochemistry and Another doctor, Kay Metcalfe, a consultant clinical geneticist, arranged for a molecular autopsy to be carried out to try to 'nd out what had been happening in Dexter's heart.
But when Mayo Clinic researchers conducted a sophisticated form of postmortem genetic testing -- known as a molecular autopsy -- they found that more than one-third died due to potentially heritable genetic defects that impair the heart's rhythm center.
The projects outlined in the agreement include studies on a range of forensically relevant genetic markers for human identity testing, pharmacogenetics for molecular autopsy, microbial forensics, and additional markers and methods to generate investigative leads in criminal cases and matters of national security.
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