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proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

moderate

said of a disease or condition that interferes with normal activities, such as eating and ambulation, without completely blocking them out.

Patient discussion about moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

More discussions about moderate
References in periodicals archive ?
The NCMS said the sea will be slight to moderate in the Arabian Gulf and Oman Sea, and coastal areas can expect winds of up to 40kph.
The Wilayat of Ja'alan Bani Bu Ali and its villages reported moderate to heavy rainfall with clouds accompanied by thunder and strong winds, resulting in the flooding of mountain passes, like the passes of Al Ghwaila, Al Hilya, Al Litaq.
At night, relatively cold weather prevails in the hilly areas but it will be moderate in other regions.
Global Markets Direct's, 'Moderate Pain - Pipeline Review, H1 2014', provides an overview of the Moderate Pain's therapeutic pipeline.
CHICAGO -- Moderate drinkers who quit after an MI have worse long-term outcomes than do those who continue light to moderate drinking, Dr.
For the main analyses, the researchers categorized participants' level of depressive symptoms as high, moderate or low; in secondary analyses, they' substituted a continuous measure of depressive symptoms.
This rigorous, large-scale study showed that the combination of glucosamine and chondroitin sulfate appeared to help people with moderate to severe pain from knee osteoarthritis, but not those with mild pain," says Stephen Straus, director of the National Center for Complementary and Alternative Medicine at the National Institutes of Health in Bethesda, Maryland.
1 primary defeated several candidates for the Kansas State Board of Education who wanted to water down the teaching of evolution, returning the board to moderate hands.
Even moderate Muslims in the open societies of the West believe that Islam's holy book, the Koran, is the final, untouched, and therefore perfect word of God.
But it's really the frontline of a larger war to keep Democrats from appealing to more moderate evangelical voters.
Through extensive interviews with key leaders of the fundamentalist movement in the SBC, Hankins concludes that, unlike their moderate brethren, fundamentalists feared that the forces of secularization were moving into the South.
To date, little has been known-about the effects of chronic moderate exposure such as that experienced by farmers and other workers who regularly use agricultural pesticides.