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Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  


said of a disease or condition that interferes with normal activities, such as eating and ambulation, without completely blocking them out.

Patient discussion about moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

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References in periodicals archive ?
Light to moderate winds blowing from southwest to southeast will prevail over the rest of Luzon and coming from southwest to west over the rest of the country with slight to moderate seas, it also said.
AaAa In the Al Batinah Region, heavy to light rains fell on the Wilayat of Barka and Sohar, heavy to moderate rains on the Wilayat of A'Rustaq which led to the overflow of Wadi Bani Souq.
The mean daily insulin drip amount was significantly higher among patients in the tight protocol group during the study period, compared with the moderate protocol group: 37.
Two of the variables that were associated with moderate or severe depression reflected women's awareness of family members' sexual health-related behaviors or concerns.
1) A Ralphs produce-truck driver suffered moderate injuries and a motorist was slightly hurt in a collision Friday on the 101.
In this environment, and with a 5050 split, Jeffords could be a kingmaker, particularly teaming up with the three moderate New England GOP colleagues he eats lunch with every Wednesday-Lincoln Chafee of Rhode Island and Olympia Snowe and Susan Collins of Maine.
It defends the moderate way, and reminds us that nearly forty years after the events of 1963 that Birmingham has not yet attained the dream of King--or those of Harmon, Carpenter, Murray, Hardin, Grafman, Durick, Ramage, and Stallings.
John's wort's effect on moderate to severe depression or on anxiety symptoms.
Will Republican moderates back-burner gay issues while they wrestle with conservatives for control?
Combined with moderate cigarette use, physiological effects of depression may boost susceptibility to tumor progression, suggest Kiecolt-Glaser and Glaser, both of the Ohio State University College of Medicine in Columbus.
Business fixed investment accelerated sharply in the first quarter of 1996 following three quarters of relatively moderate expansion; however, recent data on orders and contracts pointed, on balance, to some deceleration in business, spending on both durable equipment and nonresidential structures.
Light to moderate rains are affecting portions of Metro Manila particularly Paranaque, Muntinlupa and Las Pinas, the state weather bureau said on Friday.