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a central nervous system stimulant used in the treatment of narcolepsy.


Alertec (CA), Apo-Mofafinil (CA), Provigil

Pharmacologic class: Nonamphetamine CNS stimulant

Therapeutic class: Analeptic

Controlled substance schedule IV

Pregnancy risk category C


Unknown. Thought to stimulate CNS by decreasing the release of gamma-aminobutyric acid (a CNS depressant), thereby increasing mental alertness.


Tablets: 100 mg, 200 mg

Indications and dosages


Adults: 200 mg/day P.O. as a single dose in morning

Dosage adjustment

• Severe hepatic impairment


• Hypersensitivity to drug


Use cautiously in:
• recent myocardial infarction, unstable angina, severe hepatic impairment, hyperthyroidism, hypertension, glaucoma, anxiety
• history of left ventricular hypertrophy, ischemic ECG changes, chest pain, arrhythmias, or mitral valve prolapse with previous CNS stimulant use
• history of psychosis
• drug abuse
• pregnant or breastfeeding patients
• children (safety and efficacy not established).


• Give without food (food delays drug absorption).

Adverse reactions

CNS: headache, dizziness, nervousness, insomnia, depression, anxiety, amnesia, tremor, emotional lability

CV: hypertension, chest pain, vasodilation, hypotension, syncope, arrhythmias

EENT: abnormal vision, amblyopia, epistaxis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, dry mouth, anorexia

GU: abnormal urine, urinary retention, albuminuria, abnormal ejaculation

Hematologic: eosinophilia

Metabolic: hyperglycemia

Musculoskeletal: joint disorders, neck pain and rigidity

Respiratory: lung disorder, dyspnea, asthma

Skin: dry skin

Other: fever, chills, herpes simplex infection


Drug-drug.Carbamazepine, phenobarbital, rifampin, other CYP3A4 inducers: decreased modafinil blood level

Cyclosporine, theophylline: decreased blood levels of these drugs

Diazepam, phenytoin, propranolol, tricyclic antidepressants, warfarin: increased blood levels of these drugs

Hormonal contraceptives: decreased contraceptive efficacy

Itraconazole, ketoconazole, other CYP3A4 inhibitors: increased modafinil blood level

Methylphenidate: delayed modafinil absorption

Drug-diagnostic tests.Aspartate aminotransferase, eosinophils, gamma-glutamyl transferase, glucose: increased levels

Hepatic enzymes: abnormal levels

Patient monitoring

• Monitor respiratory and cardiovascular status, including vital signs and ECG.
• Monitor neurologic status, including mood, motor function, cognition, and emotional lability.
• Monitor blood glucose level in diabetic patient.
• Monitor patient carefully if he is also receiving MAO inhibitors. (However, interaction studies with MAO inhibitors haven't been done.)

Patient teaching

• Tell patient he may take with or without food, but that food may delay drug absorption up to 1 hour.

Advise patient to immediately report chest pain, irregular heart beats, light-headedness, or fainting.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, motor function, and alertness.
• Instruct female patient to use reliable nonhormonal contraception during and for 1 month after therapy.
• Tell diabetic patient to monitor blood glucose level closely and stay alert for hyperglycemia.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.


/mo·daf·i·nil/ (mo-daf´ĭ-nil″) a central nervous system stimulant used in the treatment of narcolepsy.


A nonamphetamine stimulant drug that causes long-lasting wakefulness, used to treat patients with narcolepsy and other disorders.


a cerebral stimulant.
indication It is used to treat narcolepsy.
contraindications Factors that prohibit its use include hyperthyroidism, hypertension, glaucoma, severe arteriosclerosis, drug abuse, cardiovascular disease, anxiety, and known hypersensitivity to this drug.
adverse effects Arrhythmias are a life-threatening effect of this drug. Other adverse effects are hyperglycemia, albuminuria, rhinitis, pharyngitis, lung disorder, dyspnea, asthma, epistaxis, abnormal vision, amblyopia, dizziness, headache, chills, stimulation, anorexia, dry mouth, diarrhea, nausea, vomiting, mouth ulcer, gingivitis, thirst, urinary retention, abnormal ejaculation, hypertension, herpes simplex, and dry skin. Common side effects include hyperactivity, insomnia, restlessness, palpitations, and tachycardia.


Provigil® Neurology A nonamphetamine antinarcoleptic used as a 1st-line treatment of excess daytime sleepiness in narcolepsy. See Narcolepsy.


A non-amphetamine (amfetamine) nervous system stimulant used to treat NARCOLEPSY and sleep apnoea. Modafinil is an ampakine that boosts the activity of the neurotransmitter glutamate. It is being widely used by people with reasons to wish to remain awake and alert. A brand name is Provigil.
References in periodicals archive ?
The AOK Bavaria intends to enter into force one by nation-wide or country-specific, closed the open procedure Off Treaty on medicine called modafinil - close N06BA07, with all interested pharmaceutical companies, non-exclusive discount agreements pursuant to ?
Present treatments comprise psychostimulants, like modafinil or amphetamine-like compounds, to fight EDS and sodium oxybate or antidepressants against cataplexy attacks.
However, Australian Medical Association President, Dr Steve Hambleton issued a severe warning against Modafinil, saying it was illegal to use or import the drug without a prescription and could lead to huge risks when not taken appropriately.
Modafinil is a novel wake-promoting agent approved in 2004 for the management of residual sleepiness in CPAP-compliant patients.
Modafinil is a medicine used for the treatment of certain types of sleeping
Teitelman psikoza bagli noroleptik kullaniminin yol actigi sedasyon ya da beyin travmasi nedeniyle asiri gunduz uykululugu olan hastalarda modafinil kullandigini bildirmistir.
To further confound the diagnosis, both often respond to treatment with stimulant medications and there is evidence of improvement in paediatric patients with attention deficit hyperactivity disorder (ADHD) who take modafinil (44).
and his colleagues randomized 631 patients undergoing four cycles of chemotherapy to receive either 200 mg modafinil daily or placebo.
NUVIGIL is the single-isomer formulation of modafinil, the active pharmaceutical ingredient contained in PROVIGIL[R] (modafinil) Tablets |C-IV|, which was approved by FDA in 1998 to improve wakefulness.
Tokyo, Japan, Apr 5, 2006 - (JCN) - Alfresa Pharma, a wholly owned subsidiary of Alfresa Holdings, has signed an agreement with Tanabe Seiyaku on modafinil, an agent for treating narcolepsy.
Poster topics were equally varied, including posters on the effects of modafinil on working memory in rats, effects of early food restriction on weight gain, psychological correlates of self-esteem, and effects of age and gender on seat belt usage.
Forwell, modafinil (Provigil) is the most useful agent available at the moment.