moclobemide


Also found in: Wikipedia.

moclobemide

A reversible mono-amine oxidase inhibitor (MAOI) used to manage depression and performance anxiety. It is not approved for use in the USA.
 
Adverse effects
Insomnia, headache, dizziness.

moclobemide

Aurorix®, Manerix® Neurology A mono-amine oxidase inhibitor used to manage depression

moclobemide

A reversible MONO-AMINE OXIDASE INHIBITOR drug used to treat severe depression and social phobia. A brand name is Manerix.
References in periodicals archive ?
Moclobemide is a reversible inhibitor of MAO with fewer adverse effects.
5 75-225 Serotonin modulators Trazodone 50 75-400 Norepinephrine-serotonin modulator (NaSSA) Mirtazapine 15 15-45 Monoamine oxidase inhibitors (MAOIs) Irreversible, nonselective Phenelzine 15 15-90 Tranylcypromine 10 30-60 Isocarboxazid 20 30-60 Reversible MAOI-A Moclobemide 300 300-600 Melatonergic agonist Agomelatine 25 25-50 * Reprinted with permission from APA Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed, [c] 2010).
Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice.
Another option is the reversible monoamine oxidate inhibitor (MAOI) moclobemide, though this agent is not approved for use in the United States.
The other drugs prescribed less frequently were mirtazapine, tianeptine, trazodone, chlorpromazine and moclobemide.
Comparison of moclobemide with selective serotonin reuptake inhibitors (SSRIs) on sexual function in depressed adults.
Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial.
Substitution rates equal to or more than 80% were found in certain pharmacological classes during the study period, that is, the tricyclic antidepressants (specifically amitriptyline [10 mg and 25 mg], dothiepin 75 mg and trimipramine 50 mg during 2004-2005 and dothiepin 25 mg during 2006) and the selective mono-amine oxidase inhibitors (including moclobemide 300 mg during 2005 and moclobemide 150 mg during 2004-2006).
Now that we know clorgyline works, we can focus future drug testing on newer, safer MAO-A inhibitors, such as moclobemide, whose chemical bindings are reversible, unlike those of clorgyline," Paolocci added.
Other antidepressants that have shown benefits in varying numbers and sizes of trials are fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole.