mixed episode


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Related to mixed episode: agitated depression, manic depression, rapid cycling

episode

 [ep´ĭ-sōd]
a single noteworthy happening in the course of a longer series of events, such as one critical period of several during a prolonged illness.
hypomanic episode a period of elevated, expansive, or irritable mood similar to a manic episode but not as severe; see also bipolar disorders and mood disorders.
major depressive episode a period of daily and day-long depressed mood or loss of interest or pleasure in virtually all activities. Also present is some combination of altered appetite, weight, or sleep patterns, psychomotor agitation or retardation, difficulty thinking or concentrating, lack of energy and fatigue, feelings of worthlessness, self-reproach, or inappropriate guilt, recurrent thoughts of death or suicide, and plans or attempts to commit suicide. See also bipolar disorders and mood disorders.
manic episode a period of predominantly elevated, expansive, or irritable mood accompanied by some of the following symptoms: inflated self-esteem, decreased need for sleep, talkativeness, flight of ideas, distractibility, hyperactivity, hypersexuality, and recklessness. See also bipolar disorders and mood disorders.
mixed episode a period during which the criteria are met both for a major depressive episode and for a manic episode nearly every day, with rapidly alternating moods and with symptoms characteristic of each type of episode. See also bipolar disorders and mood disorders.

mixed episode

1. a manifestation of a major mood disorder involving simultaneous symptoms of a manic episode and a major depressive episode.
2. a DSM construct when specified criteria are met.
A period of 1 week in which the diagnostic criteria for manic and depressive episodes are met on nearly every day, with abrupt mood swings from sadness to irritability to euphoria

mixed episode

Psychiatry A period of ≥ 1 wk in which criteria for manic and depressive episodes are met on nearly every day, with abrupt mood swings from sadness, irritability, euphoria Clinical Agitation, insomnia, appetite dysregulation, psychotic features and suicidal ideation; MEs are of sufficient severity to cause impairment of social and occupational function and/or require hospitalization. See Bipolar disorder.

mix·ed ep·i·sode

(mikst epi-sōd)
Sign of a major mood disorder involving simultaneous symptoms of manic and major depressive episodes.
See: bipolar disorder, manic episode, major depressive disorder

mix·ed ep·i·sode

(mikst epi-sōd)
Manifestation of major mood disorder involving simultaneous symptoms of a manic episode and a major depressive episode.
References in periodicals archive ?
Lundbeck today announced results from post hoc analyses in bipolar I disorder patients experiencing mixed episodes, which found asenapine has a significant effect on both manic and depressive symptoms versus placebo.
The median duration of mixed episodes might be close to a year, compared to 20-25 weeks for pure depressive and 10 weeks for pure manic episodes.
Recently, Saphris received an FDA indication for maintenance in schizophrenia after it showed superiority to placebo over a 26-week trial; it also received an indication for adjunctive therapy with either lithium or valproate for the acute treatment of manic or mixed episodes associated with bipolar I disorder.
three-week trial in adolescents with manic or mixed episodes associated with
study that led to the approval compared two fixed doses of aripiprazole to placebo in 296 outpatients, aged 10-17 years, who met DSM-IV criteria for bipolar I disorder manic or mixed episodes with or without psychotic features, and who had a Young Mania Rating Scale (YMRS) score of 20 or more at baseline.
Women have more mixed episodes and more rapid cycling than men.
Food and Drug Administration (FDA) for cariprazine for the treatment of schizophrenia and the acute treatment of manic or mixed episodes associated with Bipolar I disorder.
Food and Drug Administration (FDA) has approved VRAYLAR(TM) (cariprazine) capsules, an atypical antipsychotic, for the acute treatment of manic or mixed episodes associated with bipolar I disorder and for treatment of schizophrenia in adults.
Actavis, the Dublin-based pharmaceutical manufacturer, announced March 13 that the FDA has approved the company's supplemental new drug application for asenapine (Saphris), a second-generation atypical antipsychotic, as monotherapy for the acute treatment of manic or mixed episodes associated with bipolar I disorder in this pediatric population.
The FDA approved Risperdal in 2002 for the treatment of schizophrenia and in 2003 for the short-term treatment of acute mania and for mixed episodes associated with Bipolar 1 Disorder.
the acute treatment of schizophrenia or manic or mixed episodes associated with
The application for the acute treatment of manic or mixed episodes associated with Bipolar I Disorder includes results from three positive placebo-controlled trials in over 1000 patients, two flexible dose studies and one fixed-flexible dose study using the change from baseline in the Young Mania Rating Scale (YMRS) total score as primary efficacy endpoint.