mitoxantrone


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mitoxantrone

 [mi″to-zan´trōn]
a DNA-reactive agent of the anthracenedione group that inserts into DNA, causing crosslinks and strand breaks; administered intravenously as the hydrochloride salt as an antitumor antibiotic for the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer. It is also used to reduce the frequency and severity of relapses in patients with secondary multiple sclerosis.

mitoxantrone

/mi·to·xan·trone/ (mi″to-zan´trōn) a DNA-intercalating anthracenedione, used as the hydrochloride salt as an antineoplastic agent in the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer; also used in the treatment of secondary multiple sclerosis.

mitoxantrone

a synthetic antineoplastic antibiotic.
indications It is prescribed in combination with other approved drugs in the initial treatment of acute nonlymphocytic leukemia in adults and has activity against other leukemias, lymphoma, and breast cancer.
contraindications It should not be given to patients who are pregnant, have a clinically significant low left ventricular ejection fraction, or have evidence of prior hypersensitivity to this drug. Its use should be accompanied by close and frequent monitoring of hematologic and chemical laboratory parameters, as well as frequent patient observation.
adverse effects The side effects most often reported include hypotension, urticaria, dyspnea, rashes, phlebitis, myelosuppression, nausea, and vomiting.

mitoxantrone

Novantrone® Oncology A synthetic antitumor antibiotic Indications Combined with steroids, for treating hormone-refractory prostate CA, breast CA, AML and other lymphoproliferative malignancy and multiple sclerosis Pharmacokinetics Similar to doxorubicin Side effects Dose-limiting granulocytopenia, thrombocytopenia, N&V

mitoxantrone, mitozantrone

an anthracene derivative, similar to doxorubicin, used as an antineoplastic agent.
References in periodicals archive ?
Mitoxantrone is a drug used in the treatment of multiple sclerosis (MS), prostate cancer and leukemia.
Significantly more patients treated with docetaxel (every 3 weeks) achieved a pain response compared with patients receiving mitoxantrone (35% vs.
When the disease returned two years later, her parents enrolled her on a clinical trial in Glasgow for a treatment called mitoxantrone.
JEVTANA is the first of recently licensed drugs for the treatment of metastatic hormone refractory prostate cancer (mHRPC) to significantly extend overall survival compared to mitoxantrone in men whose disease has progressed during or after treatment containing docetaxel (15.
BCRP confers resistance to doxorubicin, camptothecin, and mitoxantrone (Mao and Unadkat 2005).
TM] with such widely employed drugs as etoposide, mitoxantrone, daunorubicin, busulfan and imatinib killed leukemia cells much more effectively than when the agents were used alone.
A study showed that children whose acute lymphoblastic leukaemia (ALL) returns have a higher chance of survival if given the drug mitoxantrone.
Patients were randomly assigned to receive an injection for up to a maximum of 10 cycles of Cabazitaxel or Mitoxantrone - a chemotherapy drug which is given to patients who develop resistance to Docetaxel.
Phase III results on Jevtana showed that treatment with Jevtana in combination with prednisone resulted in a statistically significant reduction in the risk of death compared to treatment with mitoxantrone and prednisone.
The aim of this study was to investigate the effects of AMI on lipid peroxidation, protective enzymes, and mitoxantrone (MITO]-induced acute cardiotoxicity in the rat heart using biochemical tests and histopathological examinations.
Although mitoxantrone is not approved as a treatment for advanced prostate cancer, researchers said they believed it would be more ethical to compare the new drug to an active cancer medicine rather than to a placebo.
Doctors at Walton began treating patients with a combination of a chemotherapy drug normally used to treat cancer called mitoxantrone, with an MS anti-relapse drug Copaxone, in 2001.