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a DNA-reactive agent of the anthracenedione group that inserts into DNA, causing crosslinks and strand breaks; administered intravenously as the hydrochloride salt as an antitumor antibiotic for the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer. It is also used to reduce the frequency and severity of relapses in patients with secondary multiple sclerosis.
mitoxantrone/mi·to·xan·trone/ (mi″to-zan´trōn) a DNA-intercalating anthracenedione, used as the hydrochloride salt as an antineoplastic agent in the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer; also used in the treatment of secondary multiple sclerosis.
a synthetic antineoplastic antibiotic.
indications It is prescribed in combination with other approved drugs in the initial treatment of acute nonlymphocytic leukemia in adults and has activity against other leukemias, lymphoma, and breast cancer.
contraindications It should not be given to patients who are pregnant, have a clinically significant low left ventricular ejection fraction, or have evidence of prior hypersensitivity to this drug. Its use should be accompanied by close and frequent monitoring of hematologic and chemical laboratory parameters, as well as frequent patient observation.
adverse effects The side effects most often reported include hypotension, urticaria, dyspnea, rashes, phlebitis, myelosuppression, nausea, and vomiting.
mitoxantroneNovantrone® Oncology A synthetic antitumor antibiotic Indications Combined with steroids, for treating hormone-refractory prostate CA, breast CA, AML and other lymphoproliferative malignancy and multiple sclerosis Pharmacokinetics Similar to doxorubicin Side effects Dose-limiting granulocytopenia, thrombocytopenia, N&V
an anthracene derivative, similar to doxorubicin, used as an antineoplastic agent.