This reactive process was considered in a differential diagnosis due to lack of frank tumour cell necrosis, marked cellular pleomorphism, relatively low mitotic rate
(3 mitoses/10 high power fields), and atypical mitoses.
Melanoma cancers are classified as Stage I, II, III or IV based on characteristics such as tumor thickness, mitotic rate
, ulceration, presence of lymph node involvement and distant metastasis.
13) The tumor showed large dimensions, cytologic atypia, high mitotic rate
, and necrosis.
It has a high mitotic rate
and anaplastic cytological features, and is usually observed in lymph nodes and skin, but may also affect the liver, spleen, and lungs (1), (2), (3), (4), (5).
The mitotic rate
was approximately 1 per x400 field.
Kent, the most significant change from the 2001 guidelines relates to staging, with mitotic rate
replacing Clark level of invasion as the second factor predicting melanoma survival in addition to tumor (Breslow) thickness for tumors 1 mm or smaller in thickness.
These include the American Joint Committee on Cancer criteria for staging and classification of melanomas, the mitotic rate
, nodal status, circulating tumor cell status, molecular marker status, and a history of prior nonmelanoma skin cancer or other cancers.
The tumor transitioned into more poorly differentiated areas with a round cell morphology and high mitotic rate
Microscopic findings indicated variable cellular spindle stroma with a high mitotic rate
and epithelial components, which projected leaf-like stromal proliferations lined by epithelial cells.
Current American Joint Committee on Cancer melanoma staging criteria incorporate a mitotic rate
He found that mitotic rate
and recurrence were bad prognostic factors.
By contrast, tumors that display only smooth muscle differentiation can be divided into either benign, borderline or malignant depending on several features, chief of which are mitotic rate
and tumor size.