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mitotic

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mitotic
[mītot′ik]
Etymology: Gk, mitos, thread
pertaining to or characterized by mitosis, the process of cell division in the formation of identical daughter cells.

mitotic
pertaining to mitosis.

mitotic activity
degree to which a cell population is proliferating; used as an index of tumor aggression. Can be quantified by counting the percentage of cells showing mitotic figures, or by flow cytometry.
mitotic figure
the condensed chromosomes by which a cell that is undergoing mitosis can be identified.
mitotic index
the percentage of cells simultaneously in the process of division, normally calculated after counting 1000 cells. Used in morbid pathology as a measure of the malignancy of a tumor, and in clinical pathology as an index of survival time of a neoplasm.
mitotic metaphase chromosomes
chromosomes in metaphase manifesting as mitotic figures.
mitotic nondisjunction
failure of proper disjunction of the paired chromosomes during metaphase which results in the chromosomal abnormalities of monosomy or trisomy.
mitotic potential
estimate of the cell's potential reproductive capacity.


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However, at each cell division, DNA polymerases fail to complete a full replication of the telomeres, resulting in cumulative erosion of these tail ends of the chromosomes by approximately 30-200bp after each mitotic division, and this has been likened to a 'biological clock' of ageing reflecting the number of divisions a cell may have undergone.
The same process, called mitotic catastrophe, occurs when neurons suffer DNA damage.
actually examine a range of cell death pathways beyond apoptosis, such as mitotic catastrophe and autophagy and different modes of cell growth arrest and their connections to different treatment modalities.
 
 
 
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