mitotane


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mitotane

 [mi´to-tān]
a cytotoxic compound that causes severe damage to the adrenal cortex; administered orally as an antineoplastic agent for palliative treatment of inoperable adrenocortical carcinoma.

mitotane

/mi·to·tane/ (mi´to-tān) an antineoplastic similar to the insecticide DDT; used for the treatment of inoperable adrenocortical carcinoma.

mitotane

[mī′tətān]
an antineoplastic that destroys normal and neoplastic adrenal cortical cells.
indications It is prescribed in the treatment of carcinoma of the adrenal cortex and has an unlabeled use for treating Cushing's syndrome.
contraindication Known hypersensitivity to this drug is the only contraindication.
adverse effects Among the more serious adverse effects are GI symptoms, lethargy, and adrenal insufficiency.

mitotane

Lysodren® Oncology A cytotoxic agent that controls the endocrine Sx in Pts with adrenocortical CA and ACTH producing pituitary tumors that cause Cushing's disease Adverse effects Anorexia, N&V, neurologic disturbances–ataxia, speech defects, somnolence, vertigo, lethargy, liver enzyme changes–↑ ALA, ALT, alkaline phosphatase, GGT, ↑ corticosteroid-binding globulin, ↑ sex hormone-binding globulin, ↑ cholesterol, ↓ uric acid, ↓ thyroid hormones–normal TSH. See Adrenocortical carcinoma.

mitotane

(mī´tətān´),
n brand name: Lysodren;
drug class: antineoplastic;
action: acts on adrenal cortex to suppress activity and adrenal steroid production;
use: adrenocortical carcinoma.

mitotane

an oral chemotherapeutic agent that causes selective necrosis and atrophy of the adrenocortical zona fasciculata and zona reticularis. Used in the treatment of inoperable adrenal cortical carcinoma in humans and in canine Cushing's syndrome. Called also o,p-DDD.

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References in periodicals archive ?
We excluded studies to assess the therapeutic use of o,p'-DDD iso-form, commercially known as mitotane or lysodren.
As Mitotane treatment was not available, he had chemotherapy (doxorubicin, carboplatin, and etoposide).
The post-operative course was uneventful and he was scheduled to initiate adjuvant treatment with mitotane.
Specifically, mitotane was given before surgery to the five patients with Cushing's syndrome because of hypercortisolism not amenable by other inhibitors of steroidogenesis; the remaining 3 patients were treated with mitotane as adjuvant therapy before second operation for recurrent disease.
In the systemic treatment of ACC, despite its toxicity and lower response rates, an adrenolytic agent mitotane can be used.
1-5) Aldosterone-producing adrenocortical carcinoma is treated similarly to other adrenocortical carcinomas, with surgical resection and adjuvant mitotane treatment.
Erythematous eruption of the palms and soles associated with mitotane therapy.
The most serious adverse effect associated with mitotane administration is development of total or near total adrenocortical destruction with concomitant glucocorticoid, mineralocorticoid deficiency, hyperkaliaemia and hyponatraemia (Addison's disease).
Mitotane (Lysodren [R]), which is used for both pituitary and adrenal Cushing's, was the only treatment available until recent years.
The agents inhibiting steroidogenesis include: metyrapone, ketoconazole, mitotane, aminoglutethimide, trilostane, etomidate.