mitotane


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mitotane

 [mi´to-tān]
a cytotoxic compound that causes severe damage to the adrenal cortex; administered orally as an antineoplastic agent for palliative treatment of inoperable adrenocortical carcinoma.

mitotane

/mi·to·tane/ (mi´to-tān) an antineoplastic similar to the insecticide DDT; used for the treatment of inoperable adrenocortical carcinoma.

mitotane

[mī′tətān]
an antineoplastic that destroys normal and neoplastic adrenal cortical cells.
indications It is prescribed in the treatment of carcinoma of the adrenal cortex and has an unlabeled use for treating Cushing's syndrome.
contraindication Known hypersensitivity to this drug is the only contraindication.
adverse effects Among the more serious adverse effects are GI symptoms, lethargy, and adrenal insufficiency.

mitotane

Lysodren® Oncology A cytotoxic agent that controls the endocrine Sx in Pts with adrenocortical CA and ACTH producing pituitary tumors that cause Cushing's disease Adverse effects Anorexia, N&V, neurologic disturbances–ataxia, speech defects, somnolence, vertigo, lethargy, liver enzyme changes–↑ ALA, ALT, alkaline phosphatase, GGT, ↑ corticosteroid-binding globulin, ↑ sex hormone-binding globulin, ↑ cholesterol, ↓ uric acid, ↓ thyroid hormones–normal TSH. See Adrenocortical carcinoma.

mitotane

(mī´tətān´),
n brand name: Lysodren;
drug class: antineoplastic;
action: acts on adrenal cortex to suppress activity and adrenal steroid production;
use: adrenocortical carcinoma.

mitotane

an oral chemotherapeutic agent that causes selective necrosis and atrophy of the adrenocortical zona fasciculata and zona reticularis. Used in the treatment of inoperable adrenal cortical carcinoma in humans and in canine Cushing's syndrome. Called also o,p-DDD.

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References in periodicals archive ?
There are various medications, such as ketoconazole, mitotane and metyrapone, to decrease serum cortisol for high-risk AIMAH.
Mitotane, trilostane, ketoconazole, aminoglutethimide, and metyrapone directly inhibit steroidogenesis in the adrenal glands at one or more enzymatic steps.
Ifosfamide inj, gefitinib, bendamustine, LIPEGFILGRASTIM, MITOTANE, Mitomycin, ondansetron, oxaliplatin inj, Tamoxifen, erlotinib, topotecan, topotecan caps, inj methotrexate, paclitaxel, denosumab, GADOBUTROL inj, inj GADOBENIC Acid, Glucose, Natrium Chloratum, Liquid wieloelektrolitowy, Sol Ringerii, Mannitol, Aqua pro, Hydroxyethyl starch solution KCl, Theophyll, Dextran, apparatus repeated aspiration of fluids and medications cap on the bottle, camera provides a needleless access, needle-free port, overflow device, Jonosteril Basic glucose, device type Vial Adaptor, Syringe Adapter device type, device type Spike Port Adaptor
In the systemic treatment of ACC, despite its toxicity and lower response rates, an adrenolytic agent mitotane can be used.
Steroidogenesis can be directly inhibited by agents such as ketoconazole, metyrapone, mitotane, aminoglutethimide, ortho-paradichlorodiphenyldichloroethane, and etomidate (15).
Had this ACT been diagnosed as ACC, it may have been possible and even likely to alter the patient's course by treatment with mitotane.
The agents inhibiting steroidogenesis include: metyrapone, ketoconazole, mitotane, aminoglutethimide, trilostane, etomidate.
For treatment, mitotane remains the major chemotherapeutic option for the management of adrenal carcinoma because it is a relatively specific adrenocortical cytotoxin although its capacity to prolong clinical survival is uncertain.
Response seems to be related to maintaining serum mitotane levels above 10 [micro]g/mL.
Available medications include ketoconazole, aminoglutethimide, metyrapone, mitotane, and cyproheptadine.
Cause increased thyroid- Estrogens, tamoxifen, methadone, binding globulin heroin, 5-fluorouracil, clofibrate, perphenazine, mitotane Reduce thyroid-binding Androgens, glucocorticoids, globulin aspariginase Influence absorption Cholestyramine, aluminum of thyroxine hydroxide, ferrous sulfate, sucral- fate, cation exchange resins
Cody was placed on the oral medication, mitotane (Lysodren) and because of the chronic nature of this syndrome, will receive this medication for life.