MAPK pathway

(redirected from mitogen-activated protein kinase pathway)

MAPK pathway

Mitogen-activated protein kinase pathway. An evolutionarily conserved cascade in which three families of protein kinases act in sequence to effect cell responses to various stimuli. An activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. ERK MAPKs are activated by mitogenic stimulation; CSBP2 and JNK MAPKs are activated by environmental stress (e.g., osmotic shock, UV irradiation), wound stress and inflammatory factors.
References in periodicals archive ?
Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.
Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma.
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide.
Goldstone SD, Hunt NH: Redox regulation of the mitogen-activated protein kinase pathway during lymphocyte activation.
Efstratios Katsoulidis and colleagues describe recent findings on the role of the p38 MAP kinase pathway in mediating IFN-dependent biological effects and discuss the impact of upstream and downstream pathway components on the control of cellular responses triggered by interferons in an article entitled, "The p38 Mitogen-Activated Protein Kinase Pathway in Interferon Signal Transduction.
Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.
Uterine weight and histology, vaginal opening, body and organ weights, Cd tissue retention, activation of mitogen-activated protein kinase pathways, and ERE-dependent luciferase expression were measured.
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism.
A sampling of topics: age-related changes in the degradation of oxidized proteins, the role of insulin/IGF-1 signaling pathway in aging and cancer, diabetes and the brain, protection of neural tissues and the heart by ischemic- and drug-induced preconditioning, mitogen-activated protein kinase pathways in nervous system and Alzheimer disease, molecular mechanism of HIV-1 associated neurodegeneration, and aspects of the cell biology of prions.
Amplification of 1L-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways.
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-[gamma].

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