mitogen-activated protein kinase

Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to mitogen-activated protein kinase: MAP kinase, MAPK

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
The mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that share common structural features as well as homologous pathways of activation.
Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid.
Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-[gamma].
Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells.
The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Furthermore, extracellular signal--regulated protein kinase (ERK) and p38, the members of mitogen-activated protein kinase (MAPK), have been reported to induce p53 phosphorylation at Ser15 (Bulavin et al.
JNK3 is a member of the c-Jun N-terminal kinase (JNK) subfamily of enzymes, which together with p38 mitogen-activated protein kinase and extracellular-regulated kinase (ERK) make up the larger family of structurally-related MAP kinase enzymes.
p38 Mitogen-activated protein kinase activates cNOS in endothelial cells by an estrogen receptor alpha]-dependent pathway in response to black tea polyphenols.
2]-terminal kinase (JNK), but not the activation of p38 mitogen-activated protein kinase (p38 MAPK), and then inhibited the release of leukotrienes and prostaglandin [D.
Vanadium-induced KB-dependent transcription depends upon peroxide-induced activation of the I)38 mitogen-activated protein kinase.

Full browser ?