mitogen


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to mitogen: Pokeweed mitogen

mitogen

 [mi´to-jen]
a substance that induces blast transformation; DNA, RNA, and protein synthesis; and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.

mi·to·gen

(mī'tō-jen),
A substance frequently derived from plants that stimulates mitosis and lymphocyte transformation in an antigen-nonspecific manner; includes not only lectins such as phytohemagglutinins, pokeweed mitogen, and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Synonym(s): transforming agent (1)
[mitosis + G. -gen, producing]

mitogen

/mi·to·gen/ (mīt″o-jen) a substance that induces mitosis and cell tranformation, especially lymphocyte transformation.mitogen´ic

mitogen

(mī′tə-jən)
n.
An agent that induces mitosis.

mi′to·gen′ic (mī′tə-jĕn′ĭk, mĭt′ə-) adj.
mi′to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.

mitogen

[mī′təjən, mit′-]
Etymology: Gk, mitos + genein, to produce
an agent that triggers mitosis. mitogenic, adj.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.

mitogen

1. Any agent that promotes cell nuclear division (MITOSIS). Mitogens are important in genetic research and technology. Pokeweed mitogen, derived from the plant Phytolacca americana , is a powerful mitogen of B LYMPHOCYTES.
2. Any substance that non-specifically causes lymphocytes to proliferate.

mitogen

a growth factor in the form of a small protein found in blood serum that often has a specific target organ in which it induces MITOSIS.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci and from strains of α-toxin-producing staphylococci.

mitogen,

n an agent that triggers mitosis.

mitogen

an agent that induces mitosis and lymphocyte blastogenesis.

pokeweed mitogen (PWM)
a lectin from the plant, Phytolacca americana, that produces B and T lymphocyte blastogenesis.
References in periodicals archive ?
Sunquest Mitogen LIMS and Genetic Analysis supports this move of laboratories by tracking and reporting results for clinical specimens in laboratory workflows, and by improving the management of data associated with genetic testing, and supporting clinicians in generating laboratory reports that contain genetic test results as they start or grow molecular and genetic testing services.
H]]-thymidine upon in vitro stimulation with mitogen/antigen declined in order: mitogen phytohaemagglutinin (PHA) > concanavalin A (ConA) > antigen CD3 (CD3) > pokeweed mitogen (PWM).
In this study it has been shown that the vaccine strain of PPRV (Nigeria 75/1) is capable of efficiently infecting mitogen activated goat lymphocytes in vitro.
In vitro mitogen stimulated T cell proliferation, using human whole blood cell cultures, was measured following the method of Kramer and Burri.
8) TABLE 3 Results of Mitogen Stimulation Studies Counts Per Minute Mitogen Patient Control Phytohemagglutinin 11,232 9,867 Pokeweed 7,327 3,528 Concanavalin A 12,712 4,660
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen activated protein kinases.
VEGF, clone VG-1, is a secreted glycoprotein that is a potent and specific mitogen for vascular endothelial cells that stimulates angiogenesis during embryonic development and tumor formation.
We found that mixed interleukins, but not thymosin, restored thymic weight and cellularity and enhanced thymocyte responses to interleukins and mitogen.
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.
We found that a mitogen concentration of 10 [micro]g/mL was optimal for detecting suppressive effects of compounds.
Mitogen activated protein kinases (MAPK) have been linked to hyperoxia toxicity in both cell cultures and animal models.
chronic mitogen exposure) and genetic (transduction of the propagating gene vmyc)--that are comparably safe (vmyc is constitutively downregulated by normal developmental mechanisms and environmental cues) and effective in yielding engraftable, migratory clones, suggesting that investigators may choose the propagation technique that best serves the demands of a particular research or clinical problem All clones can be cryopreserved and transplanted into multiple hosts in multiple settings.

Full browser ?