mitofusin

mitofusin

(mī-tō-fyū'zhun),
Process in which mitochondria of healthy cells undergo fusion; the course of action occurs in three steps, first, the mitochondria align themselves, end to end; next, the outer membranes of the two organelles fuse with each other; and last, the inner membranes fuse with each other, thus forming a larger mitochondrion.
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Limited Tenders are invited for Mouse Monoclonal Antibody Against Mitofusin 2 And 13 Other Items.
2] Human genes: PMP22, peripheral myelin protein 22; MPZ, myelin protein zero; GJB1, gap junction protein, beta 1, 32kDa; MFN2, mitofusin 2.
Working in mouse and fruit fly hearts, the researchers found that a protein known as mitofusin 2 (Mfn2) is the long-sought missing link in the chain of events that control mitochondrial quality.
Mitofusin 2 is known for its role in fusing mitochondria together, so they might exchange mitochondrial DNA in a primitive form of sexual reproduction.
Mitofusins 1 and 2 do pretty much the same thing in terms of mitochondrial fusion.
The ETS-responsive neuroproteome revealed significant modulation of the mitochondrial fission factor Dnm1l (or Drp1), whereas the mitochondrial fusion factor mitofusin was unresponsive to ETS exposure.
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin 2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations.
The study validates Mitofusin 2 as a possible target for the treatment of diabetes type 2.
Mitofusin 2 may provide a specific target for the development of drugs that could hold back a disease that affects millions of people worldwide", explains the head of the study, Antonio Zorzano, full professor of the University of Barcelona, coordinator of the Molecular Medicine Programme at IRB Barcelona, and head of the Heterogenic and Polygenic Diseases lab at the same centre.