2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Additionally, the dynamin-related GTPase mitofusin
2 (Mfn2) proteins located on the ER intermingle with Mfn1 or Mfn2 on mitochondria to tighten the connection.
Limited Tenders are invited for Mouse Monoclonal Antibody Against Mitofusin
2 And 13 Other Items.
2] Human genes: PMP22, peripheral myelin protein 22; MPZ, myelin protein zero; GJB1, gap junction protein, beta 1, 32kDa; MFN2, mitofusin
Hirose, "MARCH-V is a novel mitofusin
2- and Drp1-binding protein able to change mitochondrial morphology," The EMBO Reports, vol.
Working in mouse and fruit fly hearts, the researchers found that a protein known as mitofusin
2 (Mfn2) is the long-sought missing link in the chain of events that control mitochondrial quality.
2 is known for its role in fusing mitochondria together, so they might exchange mitochondrial DNA in a primitive form of sexual reproduction.
2001), the mitochondrial GTPase mitofusin
2 gene (MFN2) (Zuechner et al.
Background: Both Mitofusin
2 (Mfn2) and pelvic organ prolapse (POP) are related to aging.
Moreover, observed upregulation of mir-140, which exerts effect on mitochondrial fission and apoptosis through targeting mitofusin
1 (Mfn1), may be directly correlated with frequently observed in [ASC.
The ETS-responsive neuroproteome revealed significant modulation of the mitochondrial fission factor Dnm1l (or Drp1), whereas the mitochondrial fusion factor mitofusin
was unresponsive to ETS exposure.
Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin
2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations.