mitochondrial ribosome

mitochondrial ribosome

An intracellular structure responsible for the biosynthesis of protein components that are crucial to the generation of ATP in eukaryotic cells. Mitochondrial ribosomes resemble prokaryotic ribosomes, rather than the cytoplasmic ribosomes of the cells containing the mitochondria. The mitochondrial ribosome possesses intersubunit bridges composed largely of proteins; it has a gatelike structure at its mRNA entrance, and may be involved in recruiting unique mitochondrial mRNAs. It also has a polypeptide exit tunnel that allows access to the solvent before the exit site, suggesting a unique nascent-polypeptide exit mechanism.
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Bottger's lab, at the Institut fur Medizinische Mikrobiologie which he directs, studies aminoglycoside effects on mitochondrial ribosomes and antibacterial activity with an eye toward designing new ones.
The team's approach is to design drugs that more specifically target bacterial ribosomes over mitochondrial ribosomes, simultaneously testing the impact on hair cells as well as the ability to kill bacteria.
Additionally, Schimmer believes it's possible that chemists could design tigecycline analogues that would be more potent or more selective of mitochondrial ribosomes over bacterial ones.
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