Impaired mitochondrial respiration
and protein nitration in the rat hippocampus after acute inhalation of combustion smoke.
Some allelopathic compounds are thought to interact with the mitochondrial membrane and to impair mitochondrial respiration
With these two modifications, a broad spectrum of RNAs were targeted to and imported into the mitochondria, where they functioned to repair defects in mitochondrial respiration
and energy production in two different cell line models of human mitochondrial disease.
In muscle, resveratrol activated AMPK, increased STRT1 and PGC-1[alpha] protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration
on a fatty acid-derived substrate.
Indeed it is possible to induce this experimentally in isolated mitochondria, and is known as state 4 mitochondrial respiration
Because mitochondrial respiration
plays a critical role in glucose metabolism, mitochondrial dysfunction likewise has been shown to be associated with these conditions.
The MEGS capacity can be examined in detail by measurement of 14CO2 production rates from oxidation of [1-14C]pyruvate and carboxyl14C-labeled TCA cycle intermediates in combination with measurement of ATP production in intact mitochondria from a muscle biopsy (1), or by examining mitochondrial respiration
via oxygen consumption measurements using polarography.
Previous animal studies suggested that a reduction in mitochondrial respiration
could mimic a process called ischemic preconditioning, in which brief episodes of ischemia - a reduction in blood flow - actually protect tissue against being damaged if its blood supply is later cut off completely.
The primary factor regulating mitochondrial respiration
when oxygen and fuel substrate availability are not limiting factors, is the concentration of ADP (18) or as noted by others, the [ATP]/[ADP]x[Pi] ratio (cellular energy state) (19).
Another mechanism of GBE action is the stabilization of mitochondrial respiration
In vivo regulation of mitochondrial respiration
in cardiomyocytes: specific restrictions for intracellular diffusion of ADP.
The study also confirmed that [DELTA]mtDNA affected mitochondrial respiration
chain function and resulted in oligozoospermia, asthenozoospermia and teratozoospermia leading to infertility in mice.