Other metabolic processes, including parts of the urea cycle as well as porphyrin and steroid synthesis and maturation, also occur in the mitochondrial matrix
(Gamble and Lehninger 1973; Lambeth et al.
These 2 structures showed different sizes, and the larger one exhibited a dense crystalloid in the mitochondrial matrix
in the region opposite the axoneme (Fig.
In addition, CoQ10 also allows protons to be extruded from the mitochondrial matrix
to the intermembrane space (3), acts as a pro- or antioxidant (4), and has a role in pyrimidine biosynthesis (5) and apoptosis modulation (6).
The underling mechanism may be that the weak base tacrine is protonated in the acidic intermembrane space of mitochondria and is electrophoretically transported into the mitochondrial matrix
to release a proton in the alkaline matrix and uncouple mitochondrial respiration.
Acetylcarnitine is produced by the mitochondrial matrix
enzyme, carnitine acetyltransferase (CrAT).
Work in cultured mammalian cells and more recently in Caenorhabditis elegans has highlighted the importance of mechanisms linking perturbations in the protein-folding environment in the mitochondrial matrix
to the expression of nuclear genes encoding mitochondrial proteins.
We identified an unexpected and critical function of p53 in activating necrosis: In response to oxidative stress in normal healthy cells, p53 accumulates in the mitochondrial matrix
and triggers the opening of the PTP pore at the inner mitochondrial membrane, leading to collapse of the electrochemical gradient and cell necrosis," Moll said.
The opening of the mitochondrial PT pore produces volume dysregulation of the mitochondria, hyperosmolarity and expansion of the mitochondrial matrix
space producing outer membrane rupture.
6 nm in diameter, accumulate as a result of conformational changes to pre-existing proteins located within the IMM and mitochondrial matrix
, thus forming the mPTP.
Iron in the mitochondrial matrix
is in potentially redox-active ferrous (Fe +2) form.
The CK reaction catalysed by its mitochondrial isoenzyme MtCK in the mitochondrial intermembrane space is directed towards the synthesis of another high-energy phosphorus compound, phosphocreatine (PCr), which is liberated into the cytoplasm through the mitochondrial voltage-dependent anion selective channels (VDAC) leaving another reaction product, ADP, for further ATP resynthesis in the mitochondrial matrix
The enzyme activities of AST and GDH in cytosol released from mitochondrial matrix
changed significantly at 24 and 72 h.