Detection and quantification of mitochondrial DNA
deletions in individual cells by real-time PCR.
A compendium of human mitochondrial DNA
control region sequences: Development of an international standard forensic database, Croatian Medical Journal (2001) 42:315-327.
Dr Elson said: This is the only study to date to characterise mitochondrial DNA
errors in cholinergic neurons, a neuronal population that is highly vulnerable to cell death in Parkinsons disease patients.
Reference range of mitochondrial DNA
copy number in peripheral blood
As a result, every cell in the iPS cell line will contain the same mitochondrial DNA
mutations as that initial adult cell.
mutations associated with aging and degenerative diseases.
Harmful mutations in mitochondrial DNA
can, result in serious and life threatening diseases.
These changes in the form of telomere shortening and alterations of mitochondrial DNA
(mtDNA), are important in the aging process, and this new research provides evidence that psychosocial factors--specifically childhood adversity and psychiatric disorders-- may also influence these cellular changes and could lead to accelerated aging.
Under the new rules, IVF clinics will be able to replace a baby's defective mitochondrial DNA
with healthy DNA from a female donor's egg.
changes at a predictable rate, acting as an evolutionary clock that makes it ideal for such comparisons.
These changes are easy to identify because the mitochondrial DNA
genome is so small--just 16,000 units--compared with the three billion units of the genome in the cell's nucleus.
The first group of papers discusses protocols used to study the transduction of information from mitochondrial DNA
to functionally active respiratory complexes, covering investigations of the nucleoid proteome, mitochondrial DNA
packaging, replication, transcription, respiratory complex synthesis, and polymerase gamma mutations associated with mitochondrial disorders.