Oxidative stress, mitochondrial DNA
mutation and apoptosis in aging.
The Mitox(TM) products measure mitochondrial DNA
and RNA in clinical samples with unmatched accuracy.
Peopling of the Americas founder by four major lineages of mitochondrial DNA
, Molecular Biology and Evolution 10 (1993): 23-47; Antonio Torroni and D.
Primagen has two marketed molecular product lines; Retina Mitox products measure mitochondrial DNA
or RNA in clinical samples with unmatched accuracy and predict the onset of clinical symptoms as a result of mitochondrial toxicity.
Segregation of the G8993 mutant mitochondrial DNA
through generations and embryonic tissues in a family at risk of Leigh syndrome.
Michael Lin of the university reported supporting evidence of links between mitochondrial DNA
damage, aging, and neurodegenerative disorders.
differs from nuclear DNA in its location, its quantity in the cell, its mode of inheritance, and its sequence.
Unlike chromosomal DNA, which is an equal blend of genetic material from the mother and father, mitochondrial DNA
is handed down only by the mother.
Since mitochondria provide cells with energy, however, and since the expression of a cell's nuclear DNA is affected by its cytoplasm, modifying an egg's mitochondrial DNA
could have a range of phenotypic effects.
Using the new tests, which were approved for use only in 1995, the Pentagon compared a sample of mitochondrial DNA
removed from the pelvis last month with samples from maternal relatives of eight of the nine.
Indeed, since the percentage of mutant mitochondrial DNAs
(see Glossary on page 50) can differ among individuals in the same family and even among tissues of the same individual, the same mitochondrial DNA
mutation can cause different symptoms even in members of the same family.
Mitotyping is devoted to the forensic applications of mitochondrial DNA
(mtDNA) analysis and operates out of State College, Pennsylvania.