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Immunity against the action of a poison produced by small and gradually increasing doses of the same.
[Mithridates, King of Pontus (132-63 BCE), supposedly an unsuccessful suicide (by poison) because of repeated small doses taken to become invulnerable to assassination by poison]
Tolerance or immunity to a poison acquired by taking gradually larger doses of it.
mith′ri·dat′ic (-dăt′ĭk) adj.
acquisition of immunity to a poison by ingestion of gradually increasing amounts of it.