mithramycin


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plicamycin

 [pli″kah-mi´sin]
an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria caused by metastatic malignancy. Administered intravenously. Formerly called mithramycin.

mith·ra·my·cin

(mith'ră-mī'sin),
An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

mithramycin

/mith·ra·my·cin/ (mith″rah-mi´sin) plicamycin.

mithramycin

mithramycin

A drug that reduces bone metabolism and can be useful in the treatment of PAGET'S DISEASE and HYPERCALCAEMIA.

mith·ra·my·cin

(mith'ră-mī'sin)
An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

mithramycin

References in periodicals archive ?
The DNA-binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells," British Journal of Haematology, vol.
11) One case report associated acquired dysfibrinogenemia with mithramycin administration.
Endosperm nuclei (a combination of three endosperms per petri dish) were stained with mithramycin A (a GC-binding DNA fluorochrome; Sigma, St.
Mithramycin and 4[prime]-6-diamidino-2-phenylindole (DAPI)-DNA staining for fluorescence microspectrophotometric measurement of DNA in nuclei, plastids, and virus particles.