misoprostol


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Related to misoprostol: Mifepristone

misoprostol

 [mi″so-pros´tol]
a synthetic prostaglandin E1 analogue used to treat gastric irritation resulting from long-term therapy with nonsteroidal antiinflammatory drugs. It is also used in conjunction with mifepristone for termination of pregnancy in the first trimester. Administered orally.

misoprostol

Apo-Misoprostol (CA), Cytotec, Novo-Misoprostol (CA), PMS-Misoprostol (CA)

Pharmacologic class: Prostaglandin E1 analog

Therapeutic class: Antiulcerative, cytoprotective agent

Pregnancy risk category X

FDA Box Warning

• In pregnant women, drug can cause abortion, premature birth, or birth defects. Uterine rupture has occurred when drug was given to pregnant women to induce labor or to induce abortion beyond week 8 of pregnancy.

• Don't give to pregnant women to reduce risk of nonsteroidal anti-inflammatory drug (NSAID)-induced ulcers.

• Advise patients of drug's abortifacient property and warn them not to give it to others.

• Don't use drug to reduce risk of NSAID-induced ulcers in women of childbearing potential unless patient is at high risk for complications from gastric ulcers linked to NSAIDs or at high risk for gastric ulcers. In such patients, drug may be prescribed if patient has had negative serum pregnancy test within 2 weeks before starting therapy; is able to comply with effective contraceptive measures; has received both oral and written warnings of drug's hazards, risk of possible contraception failure, and danger to other women of childbearing potential should drug be taken by mistake; and will begin drug only on second or third day of next normal menstrual period.

Action

Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa

Availability

Tablets: 100 mcg, 200 mcg

Indications and dosages

To prevent gastric ulcers caused by NSAIDs

Adults: 200 mcg q.i.d. with food, with last daily dose given at bedtime. If intolerance occurs, decrease to 100 mcg q.i.d.

Off-label uses

• Duodenal ulcer
• Pregnancy termination

Contraindications

• Prostaglandin hypersensitivity
• Pregnancy

Precautions

Use cautiously in:
• females of childbearing age
• breastfeeding patients
• children younger than age 18 (safety not established).

Administration

Before starting therapy, make sure female patient understands dangers of taking drug while pregnant or breastfeeding.
• Be aware that drug should not be used in females of childbearing age, except those who need NSAIDs and are at high risk for complications from NSAID-associated gastric ulcers.
• For antiulcer use in females, start therapy on day 2 or 3 of normal menses.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence

GU: miscarriage, menstrual disorders, postmenopausal bleeding

Interactions

Drug-drug.Magnesium-containing antacids: increased risk of diarrhea

Patient monitoring

• Assess GI status. Report significant adverse reactions.
• Monitor menstrual pattern or postmenopausal bleeding. Report significant problems.

Patient teaching

• Instruct patient to take with food.
• Advise patient to report diarrhea, abdominal pain, and menstrual irregularities.

Tell patient drug may cause spontaneous abortion. Stress importance of using reliable contraception.
• Instruct female patient using drug for ulcer treatment to start therapy on second or third day of normal menses.
• Caution patient not to take magnesium-containing antacids, which may worsen diarrhea.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

mi·so·pros·tol

(mī'sō-prost'ol),
A prostaglandin analogue used for prevention of gastric and duodenal ulcers; particularly useful in patients taking nonsteroidal antiinflammatory drugs; antiulcerative. A component of the mifepristone-regimen for early termination of pregnancy.

misoprostol

/mi·so·pro·stol/ (mi″so-pros´tol) a synthetic prostaglandin E analogue used to treat gastric irritation resulting from long-term therapy with nonsteroidal antiinflammatory drugs; also used in conjunction with mifepristone (q.v.) for termination of pregnancy.

misoprostol

(mī′sō-prŏs′tôl′, -tōl′, -tŏl′)
n.
An oral prostaglandin analog, C22H38O5, that stimulates the production of gastric mucus and is used to prevent and treat gastric ulcers, especially in patients using NSAIDs. It is also used to induce labor and in conjunction with the drug RU 486 to induce abortion in early pregnancy.

misoprostol

A synthetic PGE1 analogue administered vaginally with mifepristone (RU 486) as an abortifacient. It is also used to prevent NSAID-induced gastric ulcers and in patients with a history of GI bleeding. Misoprostol may be of use in reducing acute rejection of renal allografts, a phenomenon partially due to ischaemic damage of kidneys that occurs between the time of “harvesting” and re-establishment of the blood flow; misoprostol-treated group subjects suffered acute rejection one-half as often as the placebo group.

When compared to PGE2, misoprostol induces complete abortion (i.e., passage of foetus and placenta simultaneously) more often (43% vs 32% for PGE2), was more convenient (insertion of two 100-µg tablets at 12 hours vs insertion of 20 mg suppository every 3 hours, plus antidiarrhoeal, antiemetic and antipyretic medication required for PGE2 therapy), was associated with fewer side effects, including fever (11% vs 63%), vomiting (4% vs 33%) and diarrhoea (4% vs 30%), and is less expensive (USD $0.97 vs $315.30).

misoprostol

Obstetrics A synthetic PGE1 analogue administered vaginally with mifepristone–RU 486 as an abortifacient, also used to manage peptic and duodenal ulcers. See Abortion, Gemeprost, Mifepristone, Sulprostone.

mi·so·pros·tol

(mī'sō-prost'ol)
1. Prostaglandin analogue used to prevent gastric and duodenal ulcers.
2. A component of the mifepristone-regimen for early termination of pregnancy.

misoprostol

A PROSTAGLANDIN drug used to treat peptic ulcers especially those caused by NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. Brand names are Cytotec and Mifegyne. The drug is also formulated with DICLOFENAC under the brand name Arthrotec, and with NAPROXEN under the brand name Napratec, for the treatment of RHEUMATOID ARTHRITIS.

mi·so·pros·tol

(mī'sō-prost'ol)
A prostaglandin analogue used to prevent gastric and duodenal ulcers; particularly useful in patients taking nonsteroidal antiinflammatory drugs.

misoprostol

(mī´sōprôs´til),
n brand name: Cytotec;
drug class: gastric mucosa protectant;
action: a prostaglandin E1 analog that inhibits gastric acid secretion;
uses: prevention of nonsteroidal antiinflammatory drug-induced gastric ulcers.

misoprostol

a synthetic analog of prostaglandin E and inhibitor of gastric secretion; used in the treatment of gastrointestinal ulceration, particularly those associated with the use of nonsteroidal anti-inflammatory drugs.
References in periodicals archive ?
If blood loss more than 500ml one hour after delivery and all traumatic causes and retained placenta were excluded, 600ug (3 tablets) of misoprostol were given per rectally, which were inserted up to a digit depth.
Tablet misoprostol 50 mcg vaginally in posterior fornix was used four hourly till the patient went into active labour or upto a maximum dose of 400 mcg.
Misoprostol was originally synthesised for use in peptic ulceration, but early in its genesis its use as a uterine stimulant began.
Working with Professor Zarko Alfirevic, Andrew Weeks from the University's Institute of Translational Medicine (ITM)'s research group have been exploring the use of oral misoprostol tablets for many years as a way to reduce the need for repeated vaginal examinations and thus reduce infection rates and increase acceptability for women.
From 124 women, 62 were managed by up to two doses of 800-ug misoprostol intra-vaginally and 62 expectantly.
A total of 12 patients who received misoprostol had complete healing at 8 weeks, compared with 4 in the placebo group (P= .
Although oxytocin remains the first-line treatment for PPH, evidence suggests that sublingual misoprostol should be considered a viable first alternative if oxytocin is not available or fails.
Recent studies indicate no significant differences in effectiveness and safety between treatment of unsafe abortion with misoprostol and surgical intervention.
Prostaglandins (PGs) are widely used for cervical ripening and labor induction; according to the Chinese guideline for cervical ripening and labor induction in late pregnancy, dinoprostone and misoprostol are both recommended.
Originally, misoprostol as a synthetic prostaglandin E1 analogue was administered for prevention and treatment of gastric ulcer diseases.
Of the 175 cases, 75 were induced with 50 [micro]g misoprostol, 50 cases with intracervical Foley's catheter No.