mismatch repair


Also found in: Acronyms.

mis·match re·pair

replacement of mismatched base pairs by removal of the incorrect base and replacement with the correct base by DNA polymerase.

mismatch repair

An intrinsic intracellular mechanism which corrects nucleotide insertion errors made during DNA replication, by excising the mismatched base pairs that escaped correction by the proofreading activities of DNA polymerases and replacing the mismatched bases with the correct ones.

mismatch repair

a DNA REPAIR mechanism that operates to correct errors caused by MISMATCH OF BASES in newly replicated DNA. The newly synthesized DNA strand containing the incorrect BASE is cut, the base removed and the correct base inserted. In ESCHERICHIA COLI, delayed METHYLATION is used as a means of distinguishing the old (parental) DNA strand from the new (daughter) strand of the newly replicated DUPLEX. A METHYL TRANSFERASE ENZYME acts slowly after DNA REPLICATION to ensure that the daughter strand remains undermethylated, relative to the parent strand, for a while. This allows the repair system to recognize the daughter strand and replace the wrong base.
References in periodicals archive ?
However, proximal tumours developed in a p53-independent manner which may indicate a preference towards the mutator phenotype with the accumulation of mutations owing to mismatch repair deficiency.
Cancer risk associated with germline DNA mismatch repair gene mutations.
The claims in this patent cover the use of different mismatch repair inhibitors for enhancing genome-wide evolution of yeast strains to yield pools of sib cells exhibiting a wide range of traits, such as sublines expressing enhanced levels of a therapeutic biologic for scaleable manufacturing, sublines suitable for generating therapeutic proteins with enhanced activity(ies), as well as strains suitable for drug screening and target discovery," added Dr.
Dunlop MG, Farrington SM, Carothers AD, et al: Cancer risk associated with germline DNA mismatch repair gene mutations.
The CE-marked Ventana MMR IHC Panel consists of Ventana anti-MLH1, Ventana anti-PMS2 (A16-4), Ventana anti-MSH2 (G219-1129), Ventana anti-MSH6 antibodies, for patients diagnosed with colorectal cancers for the detection of mismatch repair protein deficiency as an aid in the identification of probable Lynch syndrome, and Ventana BRAF V600E antibody as an aid to differentiate between sporadic colorectal cancer and probable Lynch syndrome.
The National Comprehensive Cancer Network (NCCN) panel recommends nivolumab (OPDIVO) as a category 2A treatment option in patients with metastatic deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer in second- or third-line therapy.
48 It is caused by mutations in, or affecting expression of, the DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM [through loss of expression of MSH2]).
There are a number of methods that can be used to make the clinical diagnosis of LS: analysis of family history using Amsterdam or Bethesda criteria; [13] tumour testing with immunohistochemistry (IHC) detecting the loss of DNA mismatch repair (MMR) gene product; tumour testing for microsatellite instability (MSI); or direct DNA genetic testing.
Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC): a pooled molecular reanalysis of randomized chemotherapy trials.
HNPCC is actually a group of syndromes resulting from mutation in any one of several DNA mismatch repair (MMR) genes.
Other pathways include the nucleotide-excision repair, mismatch repair, double-stranded break repair, and transcription-coupled repair pathways.
Philadelphia, PA) have patented an approach used to generate hypermutable plants through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells.