mismatch repair


Also found in: Acronyms.

mis·match re·pair

replacement of mismatched base pairs by removal of the incorrect base and replacement with the correct base by DNA polymerase.

mismatch repair

An intrinsic intracellular mechanism which corrects nucleotide insertion errors made during DNA replication, by excising the mismatched base pairs that escaped correction by the proofreading activities of DNA polymerases and replacing the mismatched bases with the correct ones.

mismatch repair

a DNA REPAIR mechanism that operates to correct errors caused by MISMATCH OF BASES in newly replicated DNA. The newly synthesized DNA strand containing the incorrect BASE is cut, the base removed and the correct base inserted. In ESCHERICHIA COLI, delayed METHYLATION is used as a means of distinguishing the old (parental) DNA strand from the new (daughter) strand of the newly replicated DUPLEX. A METHYL TRANSFERASE ENZYME acts slowly after DNA REPLICATION to ensure that the daughter strand remains undermethylated, relative to the parent strand, for a while. This allows the repair system to recognize the daughter strand and replace the wrong base.
References in periodicals archive ?
A small study published earlier this year in the New England Journal of Medicine showed that 92 per cent of patients with advanced colon and rectal cancers who had mismatch repair defects responded to Merck & Co's immunotherapy drug Keytruda.
coli); MSH2, DNA mismatch repair protein Msh2; MSH6, mutS homolog 6; PMS2, Mismatch repair endonuclease PMS2; EPCAM, epithelial cell adhesion molecule.
Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset.
Both, the protein with truncation at 659th codon (resulting from insertion of stop codon) and the protein lacking internal 31 amino acids (through skipping of exon 17), have been shown to be inactive in mismatch repair (20).
No data have been published demonstrating a relationship between mismatch repair proteins and response to therapy in GC.
She and her colleagues recently uncovered deficiencies in mismatch repair genes in some men with testicular failure, predominantly those with Sertoli-cell-only syndrome (Mol.
We hypothesize that the lack of variation may be a result of a routs homologue, mtMSH, a mismatch repair gene.
The findings concerning the genetic mutations, known as DNA mismatch repair (MMR) genes, were published this month in the British Journal of Cancer and have sparked a race against time to save those who have inherited the condition.
One of the two non-resistant lines and its resistant clone were deficient in their DNA mismatch repair systems, which results in genetic instability, increased susceptibility to neoplastic transformation, and greater development of chemoresistant cells.
Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities.
The findings provide further confirmation that the Oncotype DX Recurrence Score (RS) results improve the ability to differentiate high recurrence risk disease from low, beyond conventional factors such as T-stage, mismatch repair (MMR) status, nodes examined, grade and lymphovascular invasion.