DYRK1B

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DYRK1B

A gene on chromosome 19q12-q13.1 that encodes a dual-specificity kinase with both serine/threonine and tyrosine kinase activities. DYRK1B enhances transcriptional activity of TCF1/HNF1A and FOXO1 and inhibits epithelial cell migration; it mediates colon carcinoma cell survival in mitogen-poor environments.
References in periodicals archive ?
The recent discoveries were made during archaeological studies in the natural hills of Delazeyan and Mirk, which were first excavated around 1984.
There cam' a crash and a wailing cry, An' mirk, mirk grew the nicht: A hollow wind gaed whistling by Wi' rustling noises, thin an' dry, An fleering laughter licht-- Yet, wi' the mirth cam' a wailing sound Like a bairnie greeting sair; little child, inconsolable A sma' hand touched me, saft as snaw, snow A cauld breith sighed, "Ye maun come awa'" An I saw, nor kenned, nae mair.
In particular, we prove that the FCOLL and MIRK methods, when applied to both classes of test equations are stable, if they satisfy a condition which involves the coefficients of the methods and the number M = 2[N.
24) A late fourteenth-century rubric for extreme unction appears in John Mirk, Instructions for Parish Priests, ed.
Mill, EETS, ES 235-56, 244 (London, 1956-9), II, 533-43; John Mirk, Festial, ed.
Two research questions guided the investigation: (1) Would students' ethical sensibilities and ability to make ethically grounded decisions be advanced by using the ethical decision making framework of the Building Decision Skills curriculum of the Institute for Global Ethics (Born & Mirk, 1997)?
watch, what seemed brown bird until his kill spills as mirk does its edge of red where the fire runs under the redwing's wings and there is that tinge again and his head bends; nape of his neck in the dun shows russet just as sunset catches cloud cloudedge's slow shift shadows reach to him on their way going down his standing over the blood now, wipes bill on our scent of it with the slow smoke.
That girls are out performing boys at school, are better career candidates than their male counterparts and are fitting into the gleaming future of information technology and communication industries where men are barely graduating beyond the grunt and s mirk school of language, is news as old hat as Quentin Crisp's battered fedora.
The talented ensemble includes; Jacques and Lia Behar, Byron and Spencer Campbell, Sarah Casole, Ally and Nicholas Crane, Cassie and Tom Eubanks, Wayne Francis, Dara Goldman, Darrienne, Lauren, Adryon, and Carin Gross, Gita Gould, Olivia Hammill, Jaye Hersch, Olivia Hunter, Deborah and Jarys Maragopoulos, Joyce McWilliams, George Miller, Dan and Sarah Mirk, Charles Pepper, Shekinah Pugh, Andy Salmen, Mike Sorrell and Mike Wise.
The dim light of our one candle, with the acrid smell of the wick we forgot to snuff; the shadows in the corners of the "lang, laigh (low) mirk chamber, perishing cauld"; the driving rain on the roof close above our heads, and the gusts of wind that shook our upper windows.
Examiners pause for 10 seconds between questions to allow pupils to mirk answers.