MIR23B

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MIR23B

A gene on chromosome 9q22.32 that encodes an RNA gene.
References in periodicals archive ?
miR-3074 is a less investigated member of miR-23b cluster that its dysregulation has been reported in various cancers (30-34).
Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu, EGF, and TNF-[alpha] in breast cancer.
miRNA tailing byTUT4 and TUT7, regulation by BCDIN3D (BCDIN3 domain containing RNA methyltransfease), RNA editing by ADAR1, a reduction in RNA stability controlled by MCPIP1 (MCP-induced protein 1), and IRE1[alpha] (Ser/Thr protein kinase/endoribonuclease) regulate Dicer processing of let-7, miR-145, miR-23b, miR-146a, miR-135b, miR-17, miR-34a, miR-96, miR-125b, and miR-151 respectively.
It is predicted that miR-23b can target the conservative sequence of EV713' UTR by biological software.
Overexpression of miR-23b and anti-miR-23b resulted in down-and up-regulated production of RV1B, respectively.
Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor.
Furthermore, it has been shown that miR-23b, which is upregulated in renal cancer specimens, can directly target PRODH [encoded by proline dehydrogenase (oxidase) 1 (PRODH)], a mitochondrial tumor suppressor that induces apoptosis through the generation of reactive oxygen species and a decrease in HIF signaling (57).
miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer.
Down hsa-Iet-7a-2, let-7f-1 Bladder miR-223, miR-26b, miR-221, Up miR-103-1, miR-185, miR-23b, miR-203, miR 17-5p, miR-23.
miR-23a, miR-23b, miR-24, miR-195, miR-199a, and miR-214 were up-regulated during cardiac hypertrophy (Table 4), and their over-expression in cardiomyocytes in vitro caused an induction of hypertrophic growth.
miRNAs in human diseases Disease type miRNA Up/Down References Regulation Cardiac hypertrophy miR-23a, miR-23b, Up 74 miR-24, miR-195, miR-199a, and miR-214 Down svndroiiic miR-99a, let-7c, Up 133 miR-125b-2, miR-155 and mik-802 Alzlieimer miR9, miR128a, Up 140 mik125b Rheumalic arthritis miR-155, miR-146 Up 156 Systemic lupus crytheniatosus MiR-189, miR-61, Up 165 miR-78, MiR-21, miR-142-3p, miR-342, miR-299-3p, miR-198 and miR-298 miR-196a, miR-17-5p, Down miR-4O9-3p, mik-141, miR-383, miR-112, and miR-184 Psoriasis miR-203 Up 183