minor malformation

minor malformation

A near-extinct term for any structural defect that does not cause significant clinical disease, functional abnormalities or cosmetic problems.
References in periodicals archive ?
A meta-analysis reported that SSRIs do not increase the risk of major malformations, cardiovascular malformations, or minor malformations but that they do increase the risk of spontaneous abortions (7).
Among the minor malformations, we found a five times higher rate of angioma, benign tumours made up of small blood vessels on or near the surface of the skin.
Jones reported that 26% of children exposed to phenytoin were rated as affected with features of the anticonvulsant facies based on ratings of minor malformations, compared with 24% of those exposed to phenobarbital and only 3% of those exposed to carbamazepine.
Minor malformations include midface and digital hypoplasia, according to Dr.
In the echinacea group, six major and six minor malformations occurred; of these, four major and two minor malformations appeared in babies of women who took echinacea during the first trimester, the most important period in terms of initial fetal development.
These data include a 1997 study of pregnant women that found no significant difference in the rates of major or minor malformations, gestational age at delivery birth weight, or neonatal distress among 39 women who took cetirizine (most included first-trimester use), 81 women who took hydroxyzine (Vistaril or Atarax), and 110 controls who did not take either agent.
In addition, in the babies of the exposed versus the controlled group, the incidence of minor malformations was 5 to 1, neonatal eczema 12 to 2 and premature births 9 to 3.
4,5] Ear anomalies are common and vary from minor malformations to severe microtia.
When taken during the first trimester of pregnancy, fluoxetine seemed to increase the chance that a baby would be born with three or more minor malformations, such as fused toes.
Viot also found a greater rate of minor malformations, with 365 children suffering from angiomas (a benign skin tumour), five times higher than the overall rate.
She cited findings of minor malformations and neonatal complications with fluoxetine exposure and of increased risk of cardiovascular malformation with first trimester use of paroxetine.
Even though these three drugs probably are low-risk, there have been some reports of minor malformations with prolonged use of fluconazole and itraconazole, and data are lacking for terbinafine.