In old blood-forming stem cells, the researchers found a scarcity of specific protein components needed to form a molecular machine called the mini-chromosome
maintenance helicase, which unwinds double-stranded DNA so that the cell s genetic material can be duplicated and allocated to daughter cells later in cell division.
Among the topics are dormant replication origins, break-induced DNA replication, the mini-chromosome
maintenance replicative helicase, the spatial and temporal organization of DNA replication in bacteria and eukarya, DNA replication timing, replication-fork dynamics, sister chromatid cohesion, translesion DNA polymerases, rescuing stalled or damaged replication forks, genome instability in cancer, regulating DNA replication in plants, endoreplication, the archaeology of eukaryotic DNA replication, human mitochondrial DNA replication, whether human papillomavirus infections are warts or cancer, and adenovirus DNA replication.
Combination of Mini-Chromosome
Platform, EXZACT Precision Technology Can Bring Products to Market Faster
European firm Bayer CropScience and Chromatin Inc (Chicago, Illinois) have announced that they have entered into a technological alliance and license agreement to use Chromatin's proprietary mini-chromosome
technology for crop improvement.
Chromatin's proprietary mini-chromosome
technology allows the simultaneous introduction of multiple genes into plants without disrupting the plant's own chromosomes.
a developer of energy-crop feedstocks, today said it has used its proprietary mini-chromosome
technology to enable the improvement of sorghum with multiple new sets of genes.
Chromatin has developed a novel approach to gene stacking, using the plant's own DNA to deliver several genes on a mini-chromosome
The goal of the research program is to create a combined platform that allows for direct modification or updating of trait combinations, via EXZACT[TM], on a Mini-Chromosome
inside a plant cell in real time, thereby avoiding the need to re-engineer a new Mini-Chromosome
from the ground up.
Under the agreement, Monsanto obtains non-exclusive rights to use Chromatin's mini-chromosome
stacking technology in corn, cotton, soybeans, and canola.
announced the first demonstration that genes can be assembled, stacked, and expressed in sugarcane using the company's mini-chromosome
technology, establishing a new platform for future development of this high-value crop.
In 2000, Chromatin acquired an exclusive license for mini-chromosome
technology, developed in Dr.
With their continued commitment to extend efforts to test and develop gene stacking technologies in corn, soybean, sugar cane and other crops, this collaboration with Syngenta allows us to further implement our mini-chromosome
technology into applications that will make a difference in meeting global food, feed and fuel challenges.