mini-chromosome

mini-chromosome

(1) An artificial chromosome created by linking restriction endonuclease digested fragments of DNA.
(2) An extremely small chromosome composed of centromeres and telomeres, in contrast to a conventional chromosome, which also has a large amount of introns (intervening DNA).

New genes can be stacked onto mini-chromosomes, making it much easier to move the genes to target sites, in contrast to traditional genetic modification in which genes are incorporated into a vector and difficult to manipulate.
References in periodicals archive ?
In old blood-forming stem cells, the researchers found a scarcity of specific protein components needed to form a molecular machine called the mini-chromosome maintenance helicase, which unwinds double-stranded DNA so that the cell s genetic material can be duplicated and allocated to daughter cells later in cell division.
Among the topics are dormant replication origins, break-induced DNA replication, the mini-chromosome maintenance replicative helicase, the spatial and temporal organization of DNA replication in bacteria and eukarya, DNA replication timing, replication-fork dynamics, sister chromatid cohesion, translesion DNA polymerases, rescuing stalled or damaged replication forks, genome instability in cancer, regulating DNA replication in plants, endoreplication, the archaeology of eukaryotic DNA replication, human mitochondrial DNA replication, whether human papillomavirus infections are warts or cancer, and adenovirus DNA replication.
European firm Bayer CropScience and Chromatin Inc (Chicago, Illinois) have announced that they have entered into a technological alliance and license agreement to use Chromatin's proprietary mini-chromosome technology for crop improvement.
This piece of DNA that has been used successfully to track maternal lineage is a unique mini-chromosome called mitochondrial DNA, or mtDNA.
Chromatin's proprietary mini-chromosome technology allows the simultaneous introduction of multiple genes into plants without disrupting the plant's own chromosomes.
a developer of energy-crop feedstocks, today said it has used its proprietary mini-chromosome technology to enable the improvement of sorghum with multiple new sets of genes.
The goal of the research program is to create a combined platform that allows for direct modification or updating of trait combinations, via EXZACT[TM], on a Mini-Chromosome inside a plant cell in real time, thereby avoiding the need to re-engineer a new Mini-Chromosome from the ground up.
announced the first demonstration that genes can be assembled, stacked, and expressed in sugarcane using the company's mini-chromosome technology, establishing a new platform for future development of this high-value crop.
Chromatin has developed a novel approach to gene stacking, using the plant's own DNA to deliver several genes on a mini-chromosome.
jointly announce their intent to pursue a long term research agreement to develop mini-chromosome technology.
The panel will describe how cutting-edge plant transformation and genome modification technologies, including Chromatin's mini-chromosome technology, are changing the way agricultural crops are developed.
Jessen will oversee all facets of Chromatin's continued commercialization of its mini-chromosome gene-stacking technologies as well as lead the company's efforts to develop a portfolio of high-value biomass feedstocks targeted at the bioenergy sector.